2H42
Crystal structure of PDE5 in complex with sildenafil
Summary for 2H42
Entry DOI | 10.2210/pdb2h42/pdb |
Related | 2H40 2H44 |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | viagra, pde5, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 115058.46 |
Authors | |
Primary citation | Wang, H.,Liu, Y.,Huai, Q.,Cai, J.,Zoraghi, R.,Francis, S.H.,Corbin, J.D.,Robinson, H.,Xin, Z.,Lin, G.,Ke, H. Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281:21469-21479, 2006 Cited by PubMed: 16735511DOI: 10.1074/jbc.M512527200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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