2H42
Crystal structure of PDE5 in complex with sildenafil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 326 | 37788.5 | 3 | UniProt (O76074) Pfam (PF00233) | Homo sapiens (human) | CGB-PDE, cGMP-binding cGMP-specific phosphodiesterase |
| 2 | D, G, J (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E, H, K (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | F, I, L (A, B, C) | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE | non-polymer | 474.6 | 3 | Chemie (VIA) | |||
| 5 | M, N, O (A, B, C) | water | water | 18.0 | 311 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 113365.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1692.9 | |
| All* | Total formula weight | 115058.5 |
