PDB: 13252 件ウェブページステータス検索Chemie searchBIRD

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5KJK	SMYD2 in complex with AZ370 分子名称: (R,R)-2,3-BUTANEDIOL, 2-[2-[1-[2-(3,4-dichlorophenyl)ethyl]azetidin-3-yl]oxyphenyl]-~{N}-(3-pyrrolidin-1-ylpropyl)pyridine-4-carboxamide, N-lysine methyltransferase SMYD2, ... 著者 Ferguson, A. 登録日 2016-06-20 公開日 2016-12-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J. Med. Chem., 59, 2016
5KJL	SMYD2 in complex with AZ378 分子名称: N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ZINC ION 著者 Ferguson, A. 登録日 2016-06-20 公開日 2016-12-07 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors. J. Med. Chem., 59, 2016
6W5N	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class05) 分子名称: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (6 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6W5M	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02) 分子名称: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
7NR3	Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-[2-oxidanylidene-2-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)ethyl]-3~{H}-isoindol-1-one, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M. 登録日 2021-03-02 公開日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.897 Å) 主引用文献 Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
7NR9	Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: (2~{R})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(2-methoxypyridin-4-yl)-2-oxidanyl-ethyl]propanamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A. 登録日 2021-03-03 公開日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.906 Å) 主引用文献 Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
7NR5	Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: (2~{R})-2-[5-[5-chloranyl-2-[(2-methyl-1,2,3-triazol-4-yl)amino]pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamide, Mitogen-activated protein kinase 1, SULFATE ION 著者 O'Reilly, M, Cleasby, A. 登録日 2021-03-03 公開日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.766 Å) 主引用文献 Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
7NR8	Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2 分子名称: (2~{R})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-[6-(4-methylpiperazin-1-yl)pyridin-2-yl]-2-oxidanyl-ethyl]propanamide, 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, ... 著者 O'Reilly, M, Cleasby, A. 登録日 2021-03-03 公開日 2021-10-06 実験手法 X-RAY DIFFRACTION (1.627 Å) 主引用文献 Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64, 2021
8IB8	Human TRiC-PhLP2A-actin complex in the closed state 分子名称: ACTB protein (Fragment), Phosducin-like protein 3, T-complex protein 1 subunit alpha, ... 著者 Roh, S.H, Park, J, Kim, H, Lim, S. 登録日 2023-02-09 公開日 2023-12-20 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (4.42 Å) 主引用文献 A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle. Nat Commun, 15, 2024
7AXU	Structure of WDR5:CS-VIP8 cocrystal after illumination in situ 分子名称: WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-11-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXQ	Structure of the cryo-trapped WDR5:CS-VIP8 cocrystal after illumination at 405 nm and 180 K 分子名称: CS-VIP8, WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-12-15 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.562 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXX	Structure of WDR5:CS-VIP8 crystal after illumination at 405 nm and room temperature 分子名称: (ALQ)(4FO)R(ABA)(DPN)(EDN)(S7Z), WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-12-15 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXP	Structural characterisation of WDR5:CS-VIP8 interaction in cis state 2 分子名称: CS-VIP8, WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-12-15 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (2.432 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AXS	Structural characterisation of WDR5:CS-VIP8 interaction in cis state 1 分子名称: CS-VIP8, (ALQ)(4FO)R(ABA)(DPN)(EDN)(S7Z), WD repeat-containing protein 5 著者 Werel, L, Essen, L.-O. 登録日 2020-11-10 公開日 2021-12-15 最終更新日 2024-07-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8, 2022
7AG0	Complex between the bone morphogenetic protein 2 and its antagonist Noggin 分子名称: Bone morphogenetic protein 2, GLYCEROL, Noggin 著者 Robert, C, Bruck, F, Herman, R, Vandevenne, M, Filee, P, Kerff, F, Matagne, A. 登録日 2020-09-21 公開日 2022-04-13 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.104 Å) 主引用文献 Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition. J.Biol.Chem., 299, 2023
7AYY	Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, N-glycosylase/DNA lyase, ... 著者 Masuyer, G, Davies, J.R, Stenmark, P. 登録日 2020-11-13 公開日 2022-06-01 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science, 376, 2022
7AYZ	Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with activator TH10785 分子名称: N-glycosylase/DNA lyase, NICKEL (II) ION, ~{N}-cyclohexyl-2-cyclopropyl-quinazolin-4-amine 著者 Masuyer, G, Davies, J.R, Stenmark, P. 登録日 2020-11-13 公開日 2022-06-01 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science, 376, 2022
7AZ0	Structure of the mouse 8-oxoguanine DNA Glycosylase mOGG1 in complex with TH12161 分子名称: 2-cyclopropyl-~{N}-(4-iodophenyl)quinazolin-4-amine, N-glycosylase/DNA lyase, NICKEL (II) ION 著者 Davies, J.R, Masuyer, G, Stenmark, P. 登録日 2020-11-13 公開日 2022-06-01 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function. Science, 376, 2022
4QQE	Crystal structure of WDR5, WD repeat domain 5 in complex with compound SGC-DS-MT-0345 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, N-[2-(4-methylpiperazin-1-yl)-5-(quinolin-3-yl)phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, ... 著者 Dong, A, Dombrovski, L, Wernimont, A, Smil, D, Getlik, M, Senisterra, G, Poda, G, Al-Awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Schapira, M, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC) 登録日 2014-06-27 公開日 2014-07-30 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of WDR5, WD repeat domain 5 in complex with compound SGC-DS-MT-0345 To be Published
1JN7	Solution Structure of a CCHH mutant of the ninth CCHC Zinc Finger of U-shaped 分子名称: U-shaped TRANSCRIPTIONAL COFACTOR, ZINC ION 著者 Kowalski, K, Mackay, J.P. 登録日 2001-07-23 公開日 2002-09-25 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Characterization of the Conserved Interaction between GATA and FOG Family Proteins J.Biol.Chem., 277, 2002
1SRS	SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA 分子名称: DNA (5'-D(*CP*CP*(5IU)P*TP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*CP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*CP*AP*TP*GP*GP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*A P*AP*G)-3'), PROTEIN (SERUM RESPONSE FACTOR (SRF)) 著者 Pellegrini, L, Tan, S, Richmond, T.J. 登録日 1995-07-28 公開日 1995-07-28 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure of serum response factor core bound to DNA. Nature, 376, 1995
7T36	Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ZS1-322 分子名称: (3R)-4-[6-{1-[diamino(hydroxy)-lambda~4~-sulfanyl]cyclopropyl}-2-(methylsulfanyl)pyrimidin-4-yl]-3-methylmorpholine, 1,2-ETHANEDIOL, Transcription initiation factor TFIID subunit 1 著者 Karim, M.R, Schonbrunn, E. 登録日 2021-12-07 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ZS1-322 To Be Published
7T2I	Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-588 分子名称: 1,2-ETHANEDIOL, 4-(6-{1-[(R)-S-methanesulfonimidoyl]cyclopropyl}-2-[(3R)-3-methylmorpholin-4-yl]pyrimidin-4-yl)-1H-pyrrolo[2,3-b]pyridine, DIMETHYL SULFOXIDE, ... 著者 Karim, M.R, Schonbrunn, E. 登録日 2021-12-04 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Crystal structure of the tandem bromodomain (BD1, BD2) of human TAF1 bound to ZS1-588 To Be Published
1TAF	DROSOPHILA TBP ASSOCIATED FACTORS DTAFII42/DTAFII62 HETEROTETRAMER 分子名称: TFIID TBP ASSOCIATED FACTOR 42, TFIID TBP ASSOCIATED FACTOR 62, ZINC ION 著者 Xie, X, Kokubo, T, Cohen, S.L, Mirza, U.A, Hoffmann, A, Chait, B.T, Roeder, R.G, Nakatani, Y, Burley, S.K. 登録日 1996-06-01 公開日 1996-12-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural similarity between TAFs and the heterotetrameric core of the histone octamer. Nature, 380, 1996
5K6K	Zika virus non-structural protein 1 (NS1) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... 著者 Akey, D.L, Brown, W.C, Smith, J.L. 登録日 2016-05-24 公開日 2016-07-06 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Extended surface for membrane association in Zika virus NS1 structure. Nat.Struct.Mol.Biol., 23, 2016

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