6W5M

Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02)

Summary for 6W5M

• Entry DOI: 10.2210/pdb6w5m/pdb
• EMDB information: 21542 21543
• Descriptor: Retinoblastoma-binding protein 5, DNA (147-MER), WD repeat-containing protein 5, ... (10 entities in total)
• Functional Keywords: mll1-ncp, h3k4 methylation, transferase, transferase-structural protein-dna complex, transferase/structural protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 14
• Total formula weight: 377633.02

Authors

Park, S.H.,Lee, Y.T.,Ayoub, A.,Dou, Y.,Cho, U. (deposition date: 2020-03-13, release date: 2021-03-31, Last modification date: 2022-10-12)

• Primary citation: Lee, Y.T.,Ayoub, A.,Park, S.H.,Sha, L.,Xu, J.,Mao, F.,Zheng, W.,Zhang, Y.,Cho, U.S.,Dou, Y.; Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin.; Nat Commun, 12:2953-2953, 2021; PubMed: 34012049; DOI: 10.1038/s41467-021-23268-9

Experimental method

ELECTRON MICROSCOPY (4.6 Å)