5K6K

Zika virus non-structural protein 1 (NS1)

Summary for 5K6K

• Entry DOI: 10.2210/pdb5k6k/pdb
• Descriptor: Zika virus protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (5 entities in total)
• Functional Keywords: viral protein
• Biological source: Zika virus (ZIKV)
• Cellular location: Capsid protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: Q32ZE1
• Total number of polymer chains: 2
• Total formula weight: 87279.76

Authors

Akey, D.L.,Brown, W.C.,Smith, J.L. (deposition date: 2016-05-24, release date: 2016-07-06, Last modification date: 2024-11-13)

Primary citation

Brown, W.C.,Akey, D.L.,Konwerski, J.R.,Tarrasch, J.T.,Skiniotis, G.,Kuhn, R.J.,Smith, J.L.
Extended surface for membrane association in Zika virus NS1 structure.
Nat.Struct.Mol.Biol., 23:865-867, 2016

PubMed Abstract: The Zika virus, which has been implicated in an increase in neonatal microcephaly and Guillain-Barré syndrome, has spread rapidly through tropical regions of the world. The virulence protein NS1 functions in genome replication and host immune-system modulation. Here, we report the crystal structure of full-length Zika virus NS1, revealing an elongated hydrophobic surface for membrane association and a polar surface that varies substantially among flaviviruses.

PubMed: 27455458
DOI: 10.1038/nsmb.3268

Experimental method

X-RAY DIFFRACTION (1.89 Å)