5KJK

SMYD2 in complex with AZ370

Summary for 5KJK

• Entry DOI: 10.2210/pdb5kjk/pdb
• Related: 5KJL 5KJM 5KJN
• Descriptor: N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, (R,R)-2,3-BUTANEDIOL, ... (6 entities in total)
• Functional Keywords: smyd2, histone methyltransferase, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytosol : Q9NRG4
• Total number of polymer chains: 1
• Total formula weight: 50852.25

Authors

Ferguson, A. (deposition date: 2016-06-20, release date: 2016-12-07, Last modification date: 2023-09-27)

• Primary citation: Cowen, S.D.,Russell, D.,Dakin, L.A.,Chen, H.,Larsen, N.A.,Godin, R.,Throner, S.,Zheng, X.,Molina, A.,Wu, J.,Cheung, T.,Howard, T.,Garcia-Arenas, R.,Keen, N.,Pendleton, C.S.,Pietenpol, J.A.,Ferguson, A.D.; Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.; J. Med. Chem., 59:11079-11097, 2016; PubMed: 28002961

Experimental method

X-RAY DIFFRACTION (1.93 Å)