1SRS

SERUM RESPONSE FACTOR (SRF) CORE COMPLEXED WITH SPECIFIC SRE DNA

Summary for 1SRS

• Entry DOI: 10.2210/pdb1srs/pdb
• Descriptor: DNA (5'-D(*CP*CP*(5IU)P*TP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*CP*CP*AP*TP*G)-3'), DNA (5'-D(*CP*CP*AP*TP*GP*GP*CP*CP*TP*AP*AP*TP*TP*AP*GP*GP*A P*AP*G)-3'), PROTEIN (SERUM RESPONSE FACTOR (SRF)) (3 entities in total)
• Functional Keywords: transcription regulation, mads-domain, complex (dna binding protein-dna), transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P11831
• Total number of polymer chains: 4
• Total formula weight: 32321.66

Authors

Pellegrini, L.,Tan, S.,Richmond, T.J. (deposition date: 1995-07-28, release date: 1995-07-28, Last modification date: 2024-02-14)

Primary citation

Pellegrini, L.,Tan, S.,Richmond, T.J.
Structure of serum response factor core bound to DNA.
Nature, 376:490-498, 1995

PubMed Abstract: The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.

PubMed: 7637780
DOI: 10.1038/376490a0

Experimental method

X-RAY DIFFRACTION (3.2 Å)