7AXX

Structure of WDR5:CS-VIP8 crystal after illumination at 405 nm and room temperature

Summary for 7AXX

Entry DOI	10.2210/pdb7axx/pdb
Related	7AXP 7AXQ 7AXS 7AXU
Descriptor	WD repeat-containing protein 5, (ALQ)(4FO)R(ABA)(DPN)(EDN)(S7Z) (3 entities in total)
Functional Keywords	wdr5, cyclic strained visible-light photoswitches, mll1 complex disruption, inhibition of hematopoiesis, transferase
Biological source	Homo sapiens (human) More
Total number of polymer chains	2
Total formula weight	37551.44
Authors	Werel, L.,Essen, L.-O. (deposition date: 2020-11-10, release date: 2021-12-15, Last modification date: 2024-02-07)
Primary citation	Albert, L.,Nagpal, J.,Steinchen, W.,Zhang, L.,Werel, L.,Djokovic, N.,Ruzic, D.,Hoffarth, M.,Xu, J.,Kaspareit, J.,Abendroth, F.,Royant, A.,Bange, G.,Nikolic, K.,Ryu, S.,Dou, Y.,Essen, L.O.,Vazquez, O. Bistable Photoswitch Allows in Vivo Control of Hematopoiesis. Acs Cent.Sci., 8:57-66, 2022 Cited by PubMed: 35106373 DOI: 10.1021/acscentsci.1c00434 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.79 Å)

Structure validation