7NR8
Discovery of ASTX029, a clinical candidate which modulates the phosphorylation and catalytic activity of ERK1/2
Summary for 7NR8
Entry DOI | 10.2210/pdb7nr8/pdb |
Related | 7NQQ 7NQW 7NR3 7NRS |
Descriptor | Mitogen-activated protein kinase 1, SULFATE ION, DIMETHYL SULFOXIDE, ... (6 entities in total) |
Functional Keywords | serine/threonine kinase, signal transduction, map kinase, atp-binding protein, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43771.73 |
Authors | |
Primary citation | Heightman, T.D.,Berdini, V.,Bevan, L.,Buck, I.M.,Carr, M.G.,Courtin, A.,Coyle, J.E.,Day, J.E.H.,East, C.,Fazal, L.,Griffiths-Jones, C.M.,Howard, S.,Kucia-Tran, J.,Martins, V.,Muench, S.,Munck, J.M.,Norton, D.,O'Reilly, M.,Palmer, N.,Pathuri, P.,Peakman, T.M.,Reader, M.,Rees, D.C.,Rich, S.J.,Shah, A.,Wallis, N.G.,Walton, H.,Wilsher, N.E.,Woolford, A.J.,Cooke, M.,Cousin, D.,Onions, S.,Shannon, J.,Watts, J.,Murray, C.W. Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2. J.Med.Chem., 64:12286-12303, 2021 Cited by PubMed: 34387469DOI: 10.1021/acs.jmedchem.1c00905 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.627 Å) |
Structure validation
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