7AYY

Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785

This is a non-PDB format compatible entry.

Summary for 7AYY

• Entry DOI: 10.2210/pdb7ayy/pdb
• Descriptor: N-glycosylase/DNA lyase, ~{N}-cyclohexyl-2-cyclopropyl-quinazolin-4-amine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (5 entities in total)
• Functional Keywords: 8-oxoguanine dna glycosylase, n-glycosylase, dna lyase, dna repair, dna binding protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 5
• Total formula weight: 191716.14

Authors

Masuyer, G.,Davies, J.R.,Stenmark, P. (deposition date: 2020-11-13, release date: 2022-06-01, Last modification date: 2024-01-31)

• Primary citation: Michel, M.,Benitez-Buelga, C.,Calvo, P.A.,Hanna, B.M.F.,Mortusewicz, O.,Masuyer, G.,Davies, J.,Wallner, O.,Sanjiv, K.,Albers, J.J.,Castaneda-Zegarra, S.,Jemth, A.S.,Visnes, T.,Sastre-Perona, A.,Danda, A.N.,Homan, E.J.,Marimuthu, K.,Zhenjun, Z.,Chi, C.N.,Sarno, A.,Wiita, E.,von Nicolai, C.,Komor, A.J.,Rajagopal, V.,Muller, S.,Hank, E.C.,Varga, M.,Scaletti, E.R.,Pandey, M.,Karsten, S.,Haslene-Hox, H.,Loevenich, S.,Marttila, P.,Rasti, A.,Mamonov, K.,Ortis, F.,Schomberg, F.,Loseva, O.,Stewart, J.,D'Arcy-Evans, N.,Koolmeister, T.,Henriksson, M.,Michel, D.,de Ory, A.,Acero, L.,Calvete, O.,Scobie, M.,Hertweck, C.,Vilotijevic, I.,Kalderen, C.,Osorio, A.,Perona, R.,Stolz, A.,Stenmark, P.,Berglund, U.W.,de Vega, M.,Helleday, T.; Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.; Science, 376:1471-1476, 2022; PubMed: 35737787; DOI: 10.1126/science.abf8980

Experimental method

X-RAY DIFFRACTION (2 Å)