7AYY

Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
AAA	0003677	molecular_function	DNA binding
AAA	0003684	molecular_function	damaged DNA binding
AAA	0003824	molecular_function	catalytic activity
AAA	0004519	molecular_function	endonuclease activity
AAA	0005515	molecular_function	protein binding
AAA	0005634	cellular_component	nucleus
AAA	0005654	cellular_component	nucleoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0005829	cellular_component	cytosol
AAA	0006281	biological_process	DNA repair
AAA	0006284	biological_process	base-excision repair
AAA	0006285	biological_process	base-excision repair, AP site formation
AAA	0006289	biological_process	nucleotide-excision repair
AAA	0006355	biological_process	regulation of DNA-templated transcription
AAA	0006974	biological_process	DNA damage response
AAA	0006979	biological_process	response to oxidative stress
AAA	0008017	molecular_function	microtubule binding
AAA	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
AAA	0009314	biological_process	response to radiation
AAA	0016363	cellular_component	nuclear matrix
AAA	0016607	cellular_component	nuclear speck
AAA	0016787	molecular_function	hydrolase activity
AAA	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
AAA	0016829	molecular_function	lyase activity
AAA	0019899	molecular_function	enzyme binding
AAA	0032357	molecular_function	oxidized purine DNA binding
AAA	0032991	cellular_component	protein-containing complex
AAA	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
AAA	0034614	biological_process	cellular response to reactive oxygen species
AAA	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
AAA	0045007	biological_process	depurination
AAA	0045008	biological_process	depyrimidination
AAA	0045944	biological_process	positive regulation of transcription by RNA polymerase II
AAA	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AAA	1901291	biological_process	negative regulation of double-strand break repair via single-strand annealing
BBB	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
BBB	0003677	molecular_function	DNA binding
BBB	0003684	molecular_function	damaged DNA binding
BBB	0003824	molecular_function	catalytic activity
BBB	0004519	molecular_function	endonuclease activity
BBB	0005515	molecular_function	protein binding
BBB	0005634	cellular_component	nucleus
BBB	0005654	cellular_component	nucleoplasm
BBB	0005739	cellular_component	mitochondrion
BBB	0005759	cellular_component	mitochondrial matrix
BBB	0005829	cellular_component	cytosol
BBB	0006281	biological_process	DNA repair
BBB	0006284	biological_process	base-excision repair
BBB	0006285	biological_process	base-excision repair, AP site formation
BBB	0006289	biological_process	nucleotide-excision repair
BBB	0006355	biological_process	regulation of DNA-templated transcription
BBB	0006974	biological_process	DNA damage response
BBB	0006979	biological_process	response to oxidative stress
BBB	0008017	molecular_function	microtubule binding
BBB	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
BBB	0009314	biological_process	response to radiation
BBB	0016363	cellular_component	nuclear matrix
BBB	0016607	cellular_component	nuclear speck
BBB	0016787	molecular_function	hydrolase activity
BBB	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
BBB	0016829	molecular_function	lyase activity
BBB	0019899	molecular_function	enzyme binding
BBB	0032357	molecular_function	oxidized purine DNA binding
BBB	0032991	cellular_component	protein-containing complex
BBB	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
BBB	0034614	biological_process	cellular response to reactive oxygen species
BBB	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
BBB	0045007	biological_process	depurination
BBB	0045008	biological_process	depyrimidination
BBB	0045944	biological_process	positive regulation of transcription by RNA polymerase II
BBB	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BBB	1901291	biological_process	negative regulation of double-strand break repair via single-strand annealing
CCC	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
CCC	0003677	molecular_function	DNA binding
CCC	0003684	molecular_function	damaged DNA binding
CCC	0003824	molecular_function	catalytic activity
CCC	0004519	molecular_function	endonuclease activity
CCC	0005515	molecular_function	protein binding
CCC	0005634	cellular_component	nucleus
CCC	0005654	cellular_component	nucleoplasm
CCC	0005739	cellular_component	mitochondrion
CCC	0005759	cellular_component	mitochondrial matrix
CCC	0005829	cellular_component	cytosol
CCC	0006281	biological_process	DNA repair
CCC	0006284	biological_process	base-excision repair
CCC	0006285	biological_process	base-excision repair, AP site formation
CCC	0006289	biological_process	nucleotide-excision repair
CCC	0006355	biological_process	regulation of DNA-templated transcription
CCC	0006974	biological_process	DNA damage response
CCC	0006979	biological_process	response to oxidative stress
CCC	0008017	molecular_function	microtubule binding
CCC	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
CCC	0009314	biological_process	response to radiation
CCC	0016363	cellular_component	nuclear matrix
CCC	0016607	cellular_component	nuclear speck
CCC	0016787	molecular_function	hydrolase activity
CCC	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
CCC	0016829	molecular_function	lyase activity
CCC	0019899	molecular_function	enzyme binding
CCC	0032357	molecular_function	oxidized purine DNA binding
CCC	0032991	cellular_component	protein-containing complex
CCC	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
CCC	0034614	biological_process	cellular response to reactive oxygen species
CCC	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
CCC	0045007	biological_process	depurination
CCC	0045008	biological_process	depyrimidination
CCC	0045944	biological_process	positive regulation of transcription by RNA polymerase II
CCC	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CCC	1901291	biological_process	negative regulation of double-strand break repair via single-strand annealing
DDD	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
DDD	0003677	molecular_function	DNA binding
DDD	0003684	molecular_function	damaged DNA binding
DDD	0003824	molecular_function	catalytic activity
DDD	0004519	molecular_function	endonuclease activity
DDD	0005515	molecular_function	protein binding
DDD	0005634	cellular_component	nucleus
DDD	0005654	cellular_component	nucleoplasm
DDD	0005739	cellular_component	mitochondrion
DDD	0005759	cellular_component	mitochondrial matrix
DDD	0005829	cellular_component	cytosol
DDD	0006281	biological_process	DNA repair
DDD	0006284	biological_process	base-excision repair
DDD	0006285	biological_process	base-excision repair, AP site formation
DDD	0006289	biological_process	nucleotide-excision repair
DDD	0006355	biological_process	regulation of DNA-templated transcription
DDD	0006974	biological_process	DNA damage response
DDD	0006979	biological_process	response to oxidative stress
DDD	0008017	molecular_function	microtubule binding
DDD	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
DDD	0009314	biological_process	response to radiation
DDD	0016363	cellular_component	nuclear matrix
DDD	0016607	cellular_component	nuclear speck
DDD	0016787	molecular_function	hydrolase activity
DDD	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
DDD	0016829	molecular_function	lyase activity
DDD	0019899	molecular_function	enzyme binding
DDD	0032357	molecular_function	oxidized purine DNA binding
DDD	0032991	cellular_component	protein-containing complex
DDD	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
DDD	0034614	biological_process	cellular response to reactive oxygen species
DDD	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
DDD	0045007	biological_process	depurination
DDD	0045008	biological_process	depyrimidination
DDD	0045944	biological_process	positive regulation of transcription by RNA polymerase II
DDD	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DDD	1901291	biological_process	negative regulation of double-strand break repair via single-strand annealing
EEE	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
EEE	0003677	molecular_function	DNA binding
EEE	0003684	molecular_function	damaged DNA binding
EEE	0003824	molecular_function	catalytic activity
EEE	0004519	molecular_function	endonuclease activity
EEE	0005515	molecular_function	protein binding
EEE	0005634	cellular_component	nucleus
EEE	0005654	cellular_component	nucleoplasm
EEE	0005739	cellular_component	mitochondrion
EEE	0005759	cellular_component	mitochondrial matrix
EEE	0005829	cellular_component	cytosol
EEE	0006281	biological_process	DNA repair
EEE	0006284	biological_process	base-excision repair
EEE	0006285	biological_process	base-excision repair, AP site formation
EEE	0006289	biological_process	nucleotide-excision repair
EEE	0006355	biological_process	regulation of DNA-templated transcription
EEE	0006974	biological_process	DNA damage response
EEE	0006979	biological_process	response to oxidative stress
EEE	0008017	molecular_function	microtubule binding
EEE	0008534	molecular_function	oxidized purine nucleobase lesion DNA N-glycosylase activity
EEE	0009314	biological_process	response to radiation
EEE	0016363	cellular_component	nuclear matrix
EEE	0016607	cellular_component	nuclear speck
EEE	0016787	molecular_function	hydrolase activity
EEE	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
EEE	0016829	molecular_function	lyase activity
EEE	0019899	molecular_function	enzyme binding
EEE	0032357	molecular_function	oxidized purine DNA binding
EEE	0032991	cellular_component	protein-containing complex
EEE	0034039	molecular_function	8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
EEE	0034614	biological_process	cellular response to reactive oxygen species
EEE	0044029	biological_process	positive regulation of gene expression via chromosomal CpG island demethylation
EEE	0045007	biological_process	depurination
EEE	0045008	biological_process	depyrimidination
EEE	0045944	biological_process	positive regulation of transcription by RNA polymerase II
EEE	0140078	molecular_function	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EEE	1901291	biological_process	negative regulation of double-strand break repair via single-strand annealing

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Active site: {"description":"Schiff-base intermediate with DNA","evidences":[{"source":"PubMed","id":"9197244","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10706276","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11902834","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12578369","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12592398","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15610848","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 185

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues	2
Details	M-CSA 185

Chain

Residue

Details

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site_id	MCSA3
Number of Residues	2
Details	M-CSA 185

Chain

Residue

Details

---

site_id	MCSA4
Number of Residues	2
Details	M-CSA 185

Chain

Residue

Details

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site_id	MCSA5
Number of Residues	2
Details	M-CSA 185

Chain

Residue

Details

---