7AYY

Structure of the human 8-oxoguanine DNA Glycosylase hOGG1 in complex with activator TH10785

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	AAA, BBB, CCC, DDD, EEE	N-glycosylase/DNA lyase	polymer	337	37921.9	5	UniProt (O15527) Pfam (PF07934) Pfam (PF00730) In PDB	Homo sapiens (Human)
2	AAA, BBB, CCC, DDD, EEE	~{N}-cyclohexyl-2-cyclopropyl-quinazolin-4-amine	non-polymer		267.4	5	Chemie (SEQ)
3	AAA, BBB, EEE	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	3	Chemie (MES)
4	DDD, EEE	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5		water	water		18.0	704	Chemie (HOH)

Sequence modifications

AAA, BBB, CCC, DDD, EEE: 11 - 327 (UniProt: O15527)

PDB	External Database	Details
Met -9	-	initiating methionine
Gly -8	-	expression tag
Ser -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ser 1	-	expression tag
Ser 2	-	expression tag
Gly 3	-	expression tag
Leu 4	-	expression tag
Val 5	-	expression tag
Pro 6	-	expression tag
Arg 7	-	expression tag
Gly 8	-	expression tag
Ser 9	-	expression tag
His 10	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	189609.4
Non-Polymers*	Number of molecules	10
	Total formula weight	2106.7
All*	Total formula weight	191716.1

*Water molecules are not included.