8WM8
| Cryo-EM structure of cyanobacterial nitrate/nitrite transporter NrtBCD in complex with nitrate | 分子名称: | NITRATE ION, Nitrate transport ATP-binding protein, Nitrate transport permease protein | 著者 | Li, B, Zhou, C.Z, Chen, Y.X, Jiang, Y.L. | 登録日 | 2023-10-03 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Allosteric regulation of nitrate transporter NRT via the signaling protein PII. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8WM7
| Cryo-EM structure of cyanobacterial nitrate/nitrite transporter NrtBCD in complex with signalling protein PII | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Nitrate transport ATP-binding protein, Nitrate transport permease protein, ... | 著者 | Li, B, Zhou, C.Z, Chen, Y.X, Jiang, Y.L. | 登録日 | 2023-10-03 | 公開日 | 2024-02-28 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Allosteric regulation of nitrate transporter NRT via the signaling protein PII. Proc.Natl.Acad.Sci.USA, 121, 2024
|
|
8QPK
| Cryo-EM Structure of Pre-B+5'ss Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-02 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
8UEE
| Atomic structure of Salmonella SipA/F-actin complex by cryo-EM | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Niedzialkowska, E, Runyan, L, Kudryashova, E, Kudryashov, D.S, Egelman, E.H. | 登録日 | 2023-10-01 | 公開日 | 2023-12-27 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Stabilization of F-actin by Salmonella effector SipA resembles the structural effects of inorganic phosphate and phalloidin. Structure, 32, 2024
|
|
8QPB
| Cryo-EM Structure of Pre-B+ATP Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-01 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
8QPE
| Cryo-EM Structure of Pre-B-like Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Microfibrillar-associated protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-01 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
8QPD
| |
8QPA
| Cryo-EM Structure of Pre-B+5'ssLNG Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-10-01 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
8WM0
| Crystal structure of TNIK-thiopeptide wTP3 complex | 分子名称: | ADENOSINE, THIOPEPTIDE wTP3, TRAF2 and NCK-interacting protein kinase | 著者 | Hamada, K, Kobayashi, S, Vinogradov, A.A, Zhang, Y, Goto, Y, Suga, H, Ogata, K, Sengoku, T. | 登録日 | 2023-10-01 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A Compact Reprogrammed Genetic Code for De Novo Discovery of Proteolytically Stable Thiopeptides. J.Am.Chem.Soc., 2024
|
|
8QP9
| Cryo-EM Structure of Pre-B+AMPPNP Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-09-30 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
8QP8
| Cryo-EM Structure of Pre-B Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Pre-mRNA-processing factor 6, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-09-30 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
8UDZ
| The Structure of LTBP-49247 Fab Bound to TGFbeta1 Small Latent Complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, LTBP-49247 Fab Heavy Chain, LTBP-49247 Fab Light Chain, ... | 著者 | Streich Jr, F.C, Nicholls, S.B, Boston, C.J, Ramachandran, S. | 登録日 | 2023-09-29 | 公開日 | 2024-07-17 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | An antibody that inhibits TGF-beta 1 release from latent extracellular matrix complexes attenuates the progression of renal fibrosis. Sci.Signal., 17, 2024
|
|
8QOJ
| |
8QOT
| Structure of the mu opioid receptor bound to the antagonist nanobody NbE | 分子名称: | Anti-Fab Nanobody, Mu-type opioid receptor, NabFab HC, ... | 著者 | Yu, J, Kumar, A, Zhang, X, Martin, C, Raia, P, Manglik, A, Ballet, S, Boland, A, Stoeber, M. | 登録日 | 2023-09-29 | 公開日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural Basis of mu-Opioid Receptor-Targeting by a Nanobody Antagonist. Biorxiv, 2023
|
|
8QOZ
| Cryo-EM Structure of Pre-B+5'ss+ATPgammaS Complex (core part) | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 5'ss RNA oligo, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. | 登録日 | 2023-09-29 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 630, 2024
|
|
8UDC
| Crystal structure of TcPINK1 in complex with CYC116 | 分子名称: | (4P)-4-(2-amino-4-methyl-1,3-thiazol-5-yl)-N-[4-(morpholin-4-yl)phenyl]pyrimidin-2-amine, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | 著者 | Veyron, S, Rasool, S, Trempe, J.F. | 登録日 | 2023-09-28 | 公開日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural Characterization of a small-molecule inhibitor of PINK1, a precursor tool compound for the study of Parkinson's disease To Be Published
|
|
8QOE
| Inward-facing conformation of the ABC transporter BmrA | 分子名称: | Multidrug resistance ABC transporter ATP-binding/permease protein BmrA | 著者 | Di Cesare, M, Kaplan, E, Valimehr, S, Hanssen, E, Orelle, C, Jault, J.M. | 登録日 | 2023-09-28 | 公開日 | 2023-12-20 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | The transport activity of the multidrug ABC transporter BmrA does not require a wide separation of the nucleotide-binding domains. J.Biol.Chem., 300, 2023
|
|
8QO9
| Cryo-EM structure of a human spliceosomal B complex protomer | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... | 著者 | Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. | 登録日 | 2023-09-28 | 公開日 | 2024-01-24 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (5.29 Å) | 主引用文献 | Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins. Embo J., 43, 2024
|
|
8UCT
| Crystal structure of TcPINK1 in complex with PRT | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-{[3-(2H-1,2,3-triazol-2-yl)phenyl]amino}pyrimidine-5-carboxamide, SULFATE ION, ... | 著者 | Veyron, S, Rasool, S, Trempe, J.F. | 登録日 | 2023-09-27 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Characterization of a new family of PINK1 inhibitors To Be Published
|
|
8WKH
| Crystal structure of group 13 allergen from Blomia tropicalis | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Fatty acid-binding protein | 著者 | Zhu, K.L, Gong, Y, Cui, Y.B. | 登録日 | 2023-09-27 | 公開日 | 2023-11-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Immunobiological properties and structure analysis of group 13 allergen from Blomia tropicalis and its IgE-mediated cross-reactivity. Int.J.Biol.Macromol., 254, 2023
|
|
8QNI
| |
8QNH
| Crystal structure of the E3 ubiquitin ligase Cbl-b with an allosteric inhibitor (WO2020264398 Ex23) | 分子名称: | 2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one, E3 ubiquitin-protein ligase CBL-B, SODIUM ION, ... | 著者 | Schimpl, M. | 登録日 | 2023-09-26 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity. Acs Med.Chem.Lett., 14, 2023
|
|
8QNG
| |
8WJY
| PKMYT1_Cocrystal_Cpd 4 | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, ... | 著者 | Wang, Y, Wang, C, Liu, T, Qi, H, Chen, S, Cai, X, Zhang, M, Aliper, A, Ren, F, Ding, X, Zhavoronkov, A. | 登録日 | 2023-09-26 | 公開日 | 2023-11-22 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer. J.Med.Chem., 67, 2024
|
|
8WI0
| wt-hMRP5 inward-open | 分子名称: | ATP-binding cassette sub-family C member 5 | 著者 | Liu, Z.M, Huang, Y. | 登録日 | 2023-09-24 | 公開日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.93 Å) | 主引用文献 | Inhibition and transport mechanisms of the ABC transporter hMRP5. Nat Commun, 15, 2024
|
|