5TW8
 
 | |
5U53
 | | CTX-M-14 E166A with acylated ceftazidime molecule | | 分子名称: | ACYLATED CEFTAZIDIME, Beta-lactamase, NITRATE ION | | 著者 | Patel, M, Stojanoski, V, Sankaran, B, Prasad, B.V.V, Palzkill, T. | | 登録日 | 2016-12-06 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M beta-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation.
Biochemistry, 56, 2017
|
|
5UJ3
 | | Crystal structure of the KPC-2 beta-lactamase complexed with hydrolyzed cefotaxime | | 分子名称: | (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL | | 著者 | Pemberton, O.A, Chen, Y. | | 登録日 | 2017-01-16 | | 公開日 | 2017-04-26 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).
J. Med. Chem., 60, 2017
|
|
5TOP
 | |
5TY2
 | | Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with nafcillin | | 分子名称: | (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, CHLORIDE ION, Penicillin-binding protein 4, ... | | 著者 | Alexander, J.A.N, Strynadka, N.C.J. | | 登録日 | 2016-11-18 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.
J. Biol. Chem., 2018
|
|
5T66
 | | Crystal Structure of CTX-M-15 with 1C | | 分子名称: | (3R)-3-(cyclohexylcarbonylamino)-2-oxidanyl-3,4-dihydro-1,2-benzoxaborinine-8-carboxylic acid, Beta-lactamase | | 著者 | Cahill, S.T, Brem, J, McDonough, M.A, Schofield, C.J. | | 登録日 | 2016-09-01 | | 公開日 | 2017-02-15 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.951 Å) | | 主引用文献 | Cyclic Boronates Inhibit All Classes of beta-Lactamases.
Antimicrob. Agents Chemother., 61, 2017
|
|
5UJO
 | |
5UL8
 | |
5TOY
 | |
5VLE
 | |
5TXI
 | | Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with ceftobiprole | | 分子名称: | (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, CHLORIDE ION, GLYCEROL, ... | | 著者 | Alexander, J.A.N, Strynadka, N.C.J. | | 登録日 | 2016-11-16 | | 公開日 | 2018-05-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.
J. Biol. Chem., 2018
|
|
5UJ4
 | | Crystal structure of the KPC-2 beta-lactamase complexed with hydrolyzed faropenem | | 分子名称: | (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL | | 著者 | Pemberton, O.A, Chen, Y. | | 登録日 | 2017-01-16 | | 公開日 | 2017-04-26 | | 最終更新日 | 2019-12-11 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2).
J. Med. Chem., 60, 2017
|
|
5VTH
 | | CTX-M-14 P167S:E166A mutant | | 分子名称: | Beta-lactamase | | 著者 | Hu, L, Patel, M, Sankaran, B, Prasad, B.V.V, Palzkill, T. | | 登録日 | 2017-05-17 | | 公開日 | 2017-06-28 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M beta-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation.
Biochemistry, 56, 2017
|
|
3BFG
 | | class A beta-lactamase SED-G238C complexed with meropenem | | 分子名称: | (4R,5S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-4-methyl-4,5-d ihydro-1H-pyrrole-2-carboxylic acid, Class A beta-lactamase Sed1 | | 著者 | Pernot, L, Petrella, S, Sougakoff, W. | | 登録日 | 2007-11-21 | | 公開日 | 2007-12-18 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | acyl-intermediate structures of the class A beta-lactamase SED-G238C
To be Published
|
|
3C4P
 | | Crystal Structure of the SHV-1 Beta-lactamase/Beta-lactamase inhibitor protein (BLIP) E73M complex | | 分子名称: | Beta-lactamase SHV-1, Beta-lactamase inhibitory protein, SULFATE ION | | 著者 | Reynolds, K.A, Hanes, M.S, Thomson, J.M, Antczak, A.J, Berger, J.M, Bonomo, R.A, Kirsch, J.F, Handel, T.M. | | 登録日 | 2008-01-30 | | 公開日 | 2008-05-27 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface.
J.Mol.Biol., 382, 2008
|
|
7TI0
 | | Structure of CTX-M-15 bound to RPX-7063 at 1.5A | | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, CHLORIDE ION, ... | | 著者 | Clifton, M.C, Abendroth, J, Hecker, S.J, Edwards, T.E. | | 登録日 | 2022-01-12 | | 公開日 | 2022-05-18 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Broad-spectrum cyclic boronate beta-lactamase inhibitors featuring an intramolecular prodrug for oral bioavailability.
Bioorg.Med.Chem., 62, 2022
|
|
7U4B
 | | Ampicillin-CTX-M-15 | | 分子名称: | (2S,4S)-2-[(1S)-1-{[(2S)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase, SULFATE ION | | 著者 | Ahmadvand, P, Kang, C.H. | | 登録日 | 2022-02-28 | | 公開日 | 2022-05-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | | 主引用文献 | Characterization of Interactions between CTX-M-15 and Clavulanic Acid, Desfuroylceftiofur, Ceftiofur, Ampicillin, and Nitrocefin.
Int J Mol Sci, 23, 2022
|
|
7U6Q
 | | TEM-1 beta-lactamase | | 分子名称: | Beta-lactamase, SULFATE ION | | 著者 | Ji, Z, Boxer, S.G, Mathews, I.I. | | 登録日 | 2022-03-04 | | 公開日 | 2022-09-07 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Protein Electric Fields Enable Faster and Longer-Lasting Covalent Inhibition of beta-Lactamases.
J.Am.Chem.Soc., 144, 2022
|
|
3BYD
 | | Crystal structure of beta-lactamase OXY-1-1 from Klebsiella oxytoca | | 分子名称: | ACETATE ION, Beta-lactamase OXY-1, SULFATE ION | | 著者 | Liang, Y.-H, Wu, S.W, Su, X.-D. | | 登録日 | 2008-01-15 | | 公開日 | 2009-01-20 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Structural insights into the broadened substrate profile of the extended-spectrum beta-lactamase OXY-1-1 from Klebsiella oxytoca
Acta Crystallogr.,Sect.D, 68, 2012
|
|
3BLM
 | |
3CG5
 | |
3C7U
 | |
7TPU
 | | Crystal structure of a chitinase-modifying protein from Fusarium vanettenii (Fvan-cmp) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-lactamase domain-containing protein, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Dowling, N.V, Naumann, T.A, Price, N.P.J, Rose, D.R. | | 登録日 | 2022-01-26 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.194 Å) | | 主引用文献 | Crystal structure of a polyglycine hydrolase determined using a RoseTTAFold model.
Acta Crystallogr D Struct Biol, 79, 2023
|
|
7U8S
 | | Crystal Structure of KPC-2 with compound 2 | | 分子名称: | 3-fluoro-N-[(1R,3S)-3-(1H-tetrazol-5-yl)-2,3-dihydro-1H-inden-1-yl]benzamide, Carbapenem-hydrolyzing beta-lactamase KPC | | 著者 | Akhtar, A, Chen, Y. | | 登録日 | 2022-03-09 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Probing the binding hot spots of KPC-2 carbapenemase using reversible tetrazole-based inhibitors
To Be Published
|
|
7U70
 | | Crystal Structure of CTX-M-14 with compound 2 | | 分子名称: | 3-fluoro-N-[(1R,3S)-3-(1H-tetrazol-5-yl)-2,3-dihydro-1H-inden-1-yl]benzamide, Beta-lactamase | | 著者 | Akhtar, A, Chen, Y. | | 登録日 | 2022-03-07 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | | 主引用文献 | Probing the binding hot spots of KPC-2 carbapenemase using reversible tetrazole-based inhibitors
To Be Published
|
|
