5UJ4
Crystal structure of the KPC-2 beta-lactamase complexed with hydrolyzed faropenem
Summary for 5UJ4
| Entry DOI | 10.2210/pdb5uj4/pdb |
| Related | 5UJ3 5UL8 |
| Descriptor | Carbapenem-hydrolyzing beta-lactamase KPC, (2R)-2-[(1S,2R)-1-carboxy-2-hydroxypropyl]-5-[(2R)-oxolan-2-yl]-2,3-dihydro-1,3-thiazole-4-carboxylic acid, GLYCEROL, ... (4 entities in total) |
| Functional Keywords | carbapenemase, faropenem, beta-lactamase, complex, hydrolase-antibiotic complex, hydrolase/antibiotic |
| Biological source | Klebsiella pneumoniae |
| Total number of polymer chains | 1 |
| Total formula weight | 31202.06 |
| Authors | Pemberton, O.A.,Chen, Y. (deposition date: 2017-01-16, release date: 2017-04-26, Last modification date: 2019-12-11) |
| Primary citation | Pemberton, O.A.,Zhang, X.,Chen, Y. Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2). J. Med. Chem., 60:3525-3530, 2017 Cited by PubMed: 28388065DOI: 10.1021/acs.jmedchem.7b00158 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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