5TY2
Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with nafcillin
Summary for 5TY2
Entry DOI | 10.2210/pdb5ty2/pdb |
Descriptor | Penicillin-binding protein 4, (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, ZINC ION, ... (6 entities in total) |
Functional Keywords | hydrolase, antibiotic, hydrolase - antibiotic complex, hydrolase / antibiotic |
Biological source | Staphylococcus aureus (strain COL) |
Total number of polymer chains | 2 |
Total formula weight | 81595.31 |
Authors | Alexander, J.A.N.,Strynadka, N.C.J. (deposition date: 2016-11-18, release date: 2018-06-13, Last modification date: 2023-10-04) |
Primary citation | Alexander, J.A.N.,Chatterjee, S.S.,Hamilton, S.M.,Eltis, L.D.,Chambers, H.F.,Strynadka, N.C.J. Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus. J. Biol. Chem., 2018 Cited by PubMed: 30366985DOI: 10.1074/jbc.RA118.004952 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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