5TY2
Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with nafcillin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004180 | molecular_function | carboxypeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0009002 | molecular_function | serine-type D-Ala-D-Ala carboxypeptidase activity |
| A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| A | 0046677 | biological_process | response to antibiotic |
| B | 0004180 | molecular_function | carboxypeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0009002 | molecular_function | serine-type D-Ala-D-Ala carboxypeptidase activity |
| B | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
| B | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue NFF A 401 |
| Chain | Residue |
| A | ALA74 |
| A | TYR291 |
| A | ASP346 |
| A | CL405 |
| A | HOH513 |
| A | HOH551 |
| A | SER75 |
| A | SER139 |
| A | ALA182 |
| A | ARG241 |
| A | THR260 |
| A | GLY261 |
| A | SER262 |
| A | ASP264 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | GLU357 |
| A | GLU357 |
| A | HOH745 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 403 |
| Chain | Residue |
| A | GLU336 |
| A | HOH747 |
| B | GLU336 |
| B | GLU380 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 404 |
| Chain | Residue |
| A | TYR334 |
| A | GLU336 |
| A | HIS382 |
| B | GLU336 |
| B | HIS382 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 405 |
| Chain | Residue |
| A | SER75 |
| A | LYS78 |
| A | ASN138 |
| A | SER139 |
| A | LYS259 |
| A | NFF401 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue ZN B 402 |
| Chain | Residue |
| B | GLU357 |
| B | GLU357 |
| B | HOH762 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue CL B 403 |
| Chain | Residue |
| B | SER75 |
| B | LYS78 |
| B | ASN138 |
| B | SER139 |
| B | LYS259 |
| B | NFF401 |
| B | HOH656 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 404 |
| Chain | Residue |
| B | LYS353 |
| B | ASP358 |
| B | ASP364 |
| B | HOH722 |
| B | HOH758 |
