5TY2
Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with nafcillin
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004180 | molecular_function | carboxypeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008800 | molecular_function | beta-lactamase activity |
A | 0009002 | molecular_function | serine-type D-Ala-D-Ala carboxypeptidase activity |
A | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
A | 0046677 | biological_process | response to antibiotic |
B | 0004180 | molecular_function | carboxypeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008800 | molecular_function | beta-lactamase activity |
B | 0009002 | molecular_function | serine-type D-Ala-D-Ala carboxypeptidase activity |
B | 0030655 | biological_process | beta-lactam antibiotic catabolic process |
B | 0046677 | biological_process | response to antibiotic |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 14 |
Details | binding site for residue NFF A 401 |
Chain | Residue |
A | ALA74 |
A | TYR291 |
A | ASP346 |
A | CL405 |
A | HOH513 |
A | HOH551 |
A | SER75 |
A | SER139 |
A | ALA182 |
A | ARG241 |
A | THR260 |
A | GLY261 |
A | SER262 |
A | ASP264 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue ZN A 402 |
Chain | Residue |
A | GLU357 |
A | GLU357 |
A | HOH745 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue ZN A 403 |
Chain | Residue |
A | GLU336 |
A | HOH747 |
B | GLU336 |
B | GLU380 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue ZN A 404 |
Chain | Residue |
A | TYR334 |
A | GLU336 |
A | HIS382 |
B | GLU336 |
B | HIS382 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue CL A 405 |
Chain | Residue |
A | SER75 |
A | LYS78 |
A | ASN138 |
A | SER139 |
A | LYS259 |
A | NFF401 |
site_id | AC6 |
Number of Residues | 3 |
Details | binding site for residue ZN B 402 |
Chain | Residue |
B | GLU357 |
B | GLU357 |
B | HOH762 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue CL B 403 |
Chain | Residue |
B | SER75 |
B | LYS78 |
B | ASN138 |
B | SER139 |
B | LYS259 |
B | NFF401 |
B | HOH656 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue NA B 404 |
Chain | Residue |
B | LYS353 |
B | ASP358 |
B | ASP364 |
B | HOH722 |
B | HOH758 |