5TY2
Crystal structure of S. aureus penicillin binding protein 4 (PBP4) mutant (E183A, F241R) in complex with nafcillin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Penicillin-binding protein 4 | polymer | 359 | 40203.4 | 2 | UniProt (A0A0H2WY27) Pfam (PF00144) Pfam (PF00768) Pfam (PF09211) In PDB | Staphylococcus aureus (strain COL) | |
| 2 | A, B | (2R,4S)-2-[(1R)-1-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | non-polymer | 416.5 | 2 | Chemie (NFF) | |||
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 4 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | B | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | water | water | 18.0 | 609 | Chemie (HOH) |
Sequence modifications
A, B: 25 - 383 (UniProt: A0A0H2WY27)
| PDB | External Database | Details |
|---|---|---|
| Ala 183 | Glu 183 | engineered mutation |
| Arg 241 | Phe 241 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80406.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1188.5 | |
| All* | Total formula weight | 81595.3 |
