5UJ3

Crystal structure of the KPC-2 beta-lactamase complexed with hydrolyzed cefotaxime

Summary for 5UJ3

Entry DOI	10.2210/pdb5uj3/pdb
Related	5UJ4 5UL8
Descriptor	Carbapenem-hydrolyzing beta-lactamase KPC, (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	carbapenemase, cefotaxime, beta-lactamase, complex, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	31725.58
Authors	Pemberton, O.A.,Chen, Y. (deposition date: 2017-01-16, release date: 2017-04-26, Last modification date: 2019-12-11)
Primary citation	Pemberton, O.A.,Zhang, X.,Chen, Y. Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2). J. Med. Chem., 60:3525-3530, 2017 Cited by PubMed: 28388065 DOI: 10.1021/acs.jmedchem.7b00158 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation