7U8S

Crystal Structure of KPC-2 with compound 2

Summary for 7U8S

• Entry DOI: 10.2210/pdb7u8s/pdb
• Descriptor: Carbapenem-hydrolyzing beta-lactamase KPC, 3-fluoro-N-[(1R,3S)-3-(1H-tetrazol-5-yl)-2,3-dihydro-1H-inden-1-yl]benzamide (3 entities in total)
• Functional Keywords: beta-lactamase, tetrazole, inhibitor, complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Klebsiella pneumoniae
• Total number of polymer chains: 1
• Total formula weight: 28414.96

Authors

Akhtar, A.,Chen, Y. (deposition date: 2022-03-09, release date: 2023-03-22, Last modification date: 2023-10-25)

• Primary citation: DeFrees, K.,Cambeis, E.M.,Chen, Y.,Renslo, A.R.; Probing the binding hot spots of KPC-2 carbapenemase using reversible tetrazole-based inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)