5VLE

Ultrahigh Resolution X-Ray Crystal Structure of Ruthenocene Conjugated Penicilloate and Penilloate Products in Complex with CTX-M-14 E166A Beta-Lactamase

Summary for 5VLE

• Entry DOI: 10.2210/pdb5vle/pdb
• Descriptor: Beta-lactamase, [(1,2,3,4,5-eta)-1-(4-{[(4-carboxy-5,5-dimethyl-1,3-thiazolidin-2-yl)methyl]amino}-4-oxobutanoyl)cyclopentadienyl][(1,2,3,4,5-eta)-cyclopentadienyl]ruthenium, [(1,2,3,4,5-eta)-1-(4-{[carboxy(4-carboxy-5,5-dimethyl-1,3-thiazolidin-2-yl)methyl]amino}-4-oxobutanoyl)cyclopentadienyl][(1,2,3,4,5-eta)-cyclopentadienyl]ruthenium, ... (8 entities in total)
• Functional Keywords: beta-lactamase, organometallic, ruthenocene, ctx-m-14, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 59224.26

Authors

Lewandowski, E.M.,Chen, Y. (deposition date: 2017-04-25, release date: 2017-11-08, Last modification date: 2019-12-11)

• Primary citation: Lewandowski, E.M.,Lethbridge, K.G.,Sanishvili, R.,Skiba, J.,Kowalski, K.,Chen, Y.; Mechanisms of proton relay and product release by Class A beta-lactamase at ultrahigh resolution.; FEBS J., 285:87-100, 2018; PubMed: 29095570; DOI: 10.1111/febs.14315

Experimental method

X-RAY DIFFRACTION (0.85 Å)