5TXI

Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with ceftobiprole

Summary for 5TXI

Entry DOI	10.2210/pdb5txi/pdb
Related	5TW4 5TW8 5TX9
Descriptor	Penicillin binding protein 4, (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, SULFATE ION, ... (8 entities in total)
Functional Keywords	hydrolase, antibiotic, hydrolase - antibiotic complex, hydrolase / antibiotic
Biological source	Staphylococcus aureus
Total number of polymer chains	2
Total formula weight	82284.72
Authors	Alexander, J.A.N.,Strynadka, N.C.J. (deposition date: 2016-11-16, release date: 2018-05-16, Last modification date: 2023-10-04)
Primary citation	Alexander, J.A.N.,Chatterjee, S.S.,Hamilton, S.M.,Eltis, L.D.,Chambers, H.F.,Strynadka, N.C.J. Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus. J. Biol. Chem., 2018 Cited by PubMed: 30366985 DOI: 10.1074/jbc.RA118.004952 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation