5TW8

Crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4) in complex with ceftaroline

Summary for 5TW8

• Entry DOI: 10.2210/pdb5tw8/pdb
• Related: 5TW4
• Descriptor: Penicillin-binding protein 4, Ceftaroline, bound form, ZINC ION, ... (5 entities in total)
• Functional Keywords: hydrolase, penicillin binding protein, beta-lactam antibiotics, hydrolase - antibiotic complex, hydrolase / antibiotic
• Biological source: Staphylococcus aureus (strain COL)
• Total number of polymer chains: 2
• Total formula weight: 82002.91

Authors

Alexander, J.A.N.,Strynadka, N.C.J. (deposition date: 2016-11-11, release date: 2018-05-16, Last modification date: 2023-10-04)

• Primary citation: Alexander, J.A.N.,Chatterjee, S.S.,Hamilton, S.M.,Eltis, L.D.,Chambers, H.F.,Strynadka, N.C.J.; Structural and kinetic analysis of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.; J. Biol. Chem., 2018; PubMed: 30366985; DOI: 10.1074/jbc.RA118.004952

Experimental method

X-RAY DIFFRACTION (1.72 Å)