PDB: 10970 件ウェブページステータス検索Chemie searchBIRD

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4U1G	Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to monoclonal antibody QA1 分子名称: QA1 monoclonal antibody heavy chain, QA1 monoclonal antibody light chain, Reticulocyte binding protein 5 著者 Wright, K.E, Hjerrild, K.A, Bartlett, J, Douglas, A.D, Jin, J, Brown, R.E, Ashfield, R, Clemmensen, S.B, de Jongh, W.A, Draper, S.J, Higgins, M.K. 登録日 2014-07-15 公開日 2014-08-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies. Nature, 515, 2014
4LW6	Crystal structure of catalytic domain of Drosophila beta1,4galactosyltransferase 7 complex with xylobiose 分子名称: 2-AMINO-1,3-PROPANEDIOL, Beta-4-galactosyltransferase 7, MANGANESE (II) ION, ... 著者 Qasba, P.K, Ramakrishnan, B. 登録日 2013-07-26 公開日 2013-09-25 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structures of beta-1,4-Galactosyltransferase 7 Enzyme Reveal Conformational Changes and Substrate Binding. J.Biol.Chem., 288, 2013
6RPC	GOLGI ALPHA-MANNOSIDASE II 分子名称: 1,2-ETHANEDIOL, Alpha-mannosidase 2, SUCCINIC ACID, ... 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, Debets, M, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-14 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
6S1X	X-ray structure of human glutamate carboxypeptidase II (GCPII)-E424M inactive mutant, in complex with a inhibitor KB1160 分子名称: (2~{S})-2-[[(3~{S})-3-[3-[(4-iodophenyl)carbonylamino]propanoylamino]-4-oxidanyl-4-oxidanylidene-butyl]carbamoylamino]pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Barinka, C, Kutil, Z. 登録日 2019-06-19 公開日 2020-05-13 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Novel beta- and gamma-Amino Acid-Derived Inhibitors of Prostate-Specific Membrane Antigen. J.Med.Chem., 63, 2020
4OC3	X-ray structure of of human glutamate carboxypeptidase II (GCPII) in a complex with CFIBzL, a urea-based inhibitor N~2~-{[(1S)-1-carboxy-2-(furan-2-yl)ethyl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Pavlicek, J, Ptacek, J, Cerny, J, Byun, Y, Skultetyova, L, Pomper, M, Lubkowski, J, Barinka, C. 登録日 2014-01-08 公開日 2014-05-21 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II. Bioorg.Med.Chem.Lett., 24, 2014
4OME	X-ray structure of human glutamate carboxypeptidase II in complex with DCCBL, a urea based inhibitor with distal carborane moiety 分子名称: (S)-2-(3-((S)-1-carboxy-5-(1,2-dicarba-closo-dodecarboranylamido) pentyl)ureido)pentanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Barinka, C, Ptacek, J, Novakova, Z, Byun, Y. 登録日 2014-01-27 公開日 2015-02-18 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 X-ray structure of human glutamate carboxypeptidase II in complex with DCCBL, a urea based inhibitor with distal carborane moiety To be Published
6RS0	GOLGI ALPHA-MANNOSIDASE II in complex with (2S,3S,4R,5R)-1-(2-(Benzyloxy)ethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol 分子名称: (2~{S},3~{S},4~{R})-2-(hydroxymethyl)-1-(2-phenylmethoxyethyl)piperidine-3,4,5-triol, 1,2-ETHANEDIOL, Alpha-mannosidase 2, ... 著者 Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. 登録日 2019-05-20 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020
4TUX	drosophila stem-loop binding protein complexed with histone mRNA stem-loop 分子名称: CALCIUM ION, Histone RNA hairpin-binding protein, RNA (26-MER) 著者 Zhang, J. 登録日 2014-06-25 公開日 2014-07-16 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Molecular mechanisms for the regulation of histone mRNA stem-loop-binding protein by phosphorylation. Proc.Natl.Acad.Sci.USA, 111, 2014
4TWE	Structure of ligand-free N-acetylated-alpha-linked-acidic-dipeptidase like protein (NAALADaseL) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Tykvart, J, Barinka, C, Lubkowski, J, Sacha, P, Konvalinka, J. 登録日 2014-06-30 公開日 2015-03-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and biochemical characterization of a novel aminopeptidase from human intestine. J.Biol.Chem., 290, 2015
6TYY	Hedgehog autoprocessing mutant D46H 分子名称: Protein hedgehog 著者 Li, H, Li, Z, Wang, C, Callahan, B.P. 登録日 2019-08-09 公開日 2019-11-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 General Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing. J.Am.Chem.Soc., 141, 2019
4U0Q	Plasmodium falciparum reticulocyte-binding protein homologue 5 (PfRH5) bound to basigin 分子名称: Basigin, Reticulocyte binding protein 5 著者 Wright, K.E, Hjerrild, K.A, Bartlett, J, Douglas, A.D, Jin, J, Brown, R.E, Ashfield, R, Clemmensen, S.B, de Jongh, W.A, Draper, S.J, Higgins, M.K. 登録日 2014-07-14 公開日 2014-08-13 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies. Nature, 515, 2014
4MCQ	A high resolution structure of human glutamate carboxypeptidase II (GCPII) in complex with folyldi-gamma-L-glutamic acid (pteroyltri-gamma-L-glutamic acid) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Navratil, M, Barinka, C. 登録日 2013-08-21 公開日 2014-06-18 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II. Febs J., 281, 2014
4KMA	Crystal structure of Drosophila Suppressor of Fused 分子名称: GM14141p 著者 Zhang, Y, Qi, X, Zhang, Z, Wu, G. 登録日 2013-05-08 公開日 2013-11-20 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci. Nat Commun, 4, 2013
4OC4	X-ray structure of of human glutamate carboxypeptidase II (GCPII) in a complex with CPIBzL, a urea-based inhibitor N~2~-{[(1S)-1-carboxy-2-(pyridin-4-yl)ethyl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Pavlicek, J, Ptacek, J, Cerny, J, Byun, Y, Skultetyova, L, Pomper, M, Lubkowski, J, Barinka, C. 登録日 2014-01-08 公開日 2014-05-21 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II. Bioorg.Med.Chem.Lett., 24, 2014
4U68	Crystal structure of Rhino chromodomain in complex with H3K9me3 分子名称: H3K9me3, Rhino 著者 Yu, B.W, Huang, Y. 登録日 2014-07-28 公開日 2015-08-05 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural insights into Rhino-mediated germline piRNA cluster formation Cell Res., 25, 2015
4K24	Structure of anti-uPAR Fab ATN-658 in complex with uPAR 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Urokinase plasminogen activator surface receptor, ... 著者 Huang, M.D, Xu, X, Yuan, C. 登録日 2013-04-08 公開日 2014-02-26 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b ( alpha M) Plos One, 9, 2014
4OJE	Crystal structure of a C-terminally truncated trimeric ectodomain of the C. elegans fusion protein EFF-1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EFF-1A, ... 著者 Krey, T, Rey, F.A. 登録日 2014-01-21 公開日 2014-05-14 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.57 Å) 主引用文献 Structural basis of eukaryotic cell-cell fusion Cell(Cambridge,Mass.), 157, 2014
4KP4	Deciphering cis-trans directionality and visualizing autophosphorylation in histidine kinases. 分子名称: DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, Osmolarity sensor protein EnvZ, ... 著者 Casino, P, Miguel-Romero, L, Marina, A. 登録日 2013-05-13 公開日 2014-02-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Visualizing autophosphorylation in histidine kinases. Nat Commun, 5, 2014
4OJD	Crystal structure of a C-terminally truncated trimeric ectodomain of the C. elegans fusion protein EFF-1 G260A/D321E/D322E mutant 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, EFF-1A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose 著者 Krey, T, Rey, F.A. 登録日 2014-01-21 公開日 2014-05-14 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Structural basis of eukaryotic cell-cell fusion Cell(Cambridge,Mass.), 157, 2014
4OC2	X-ray structure of of human glutamate carboxypeptidase II (GCPII) in a complex with CEIBzL, a urea-based inhibitor N~2~-{[(1S)-1-carboxybut-3-yn-1-yl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Pavlicek, J, Ptacek, J, Cerny, J, Byun, Y, Skultetyova, L, Pomper, M, Lubkowski, J, Barinka, C. 登録日 2014-01-08 公開日 2014-05-21 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II. Bioorg.Med.Chem.Lett., 24, 2014
4OFI	Crystal Structure of Duf (Kirre) D1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Kin of irre, isoform A, ... 著者 Ozkan, E, Garcia, K.C. 登録日 2014-01-14 公開日 2014-02-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Extracellular Architecture of the SYG-1/SYG-2 Adhesion Complex Instructs Synaptogenesis. Cell(Cambridge,Mass.), 156, 2014
4OC1	X-ray structure of of human glutamate carboxypeptidase II (GCPII) in a complex with COIBzL, a urea-based inhibitor (2S)-2-[({(1S)-1-carboxy-2-[(2S)-oxiran-2-yl]ethyl}carbamoyl)amino]-6-[(4-iodobenzoyl)amino]hexanoic acid 分子名称: (2S)-2-[({(1S)-1-carboxy-2-[(2S)-oxiran-2-yl]ethyl}carbamoyl)amino]-6-[(4-iodobenzoyl)amino]hexanoic acid (non-preferred name), 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Pavlicek, J, Ptacek, J, Cerny, J, Byun, Y, Skultetyova, L, Pomper, M, Lubkowski, J, Barinka, C. 登録日 2014-01-08 公開日 2014-05-21 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II. Bioorg.Med.Chem.Lett., 24, 2014
4OJC	Crystal structure of the wild-type full-length trimeric ectodomain of the C. elegans fusion protein EFF-1 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EFF-1A, ... 著者 Krey, T, Rey, F.A. 登録日 2014-01-21 公開日 2014-05-14 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.93 Å) 主引用文献 Structural basis of eukaryotic cell-cell fusion Cell(Cambridge,Mass.), 157, 2014
4NGM	Crystal Structure of Glutamate Carboxypeptidase II in a complex with urea-based inhibitor 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Tykvart, J, Pachl, P. 登録日 2013-11-02 公開日 2014-06-18 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Rational design of urea-based glutamate carboxypeptidase II (GCPII) inhibitors as versatile tools for specific drug targeting and delivery. Bioorg.Med.Chem., 22, 2014
4NDL	Computational design and experimental verification of a symmetric homodimer 分子名称: ENH-c2b, computational designed homodimer 著者 Mou, Y, Huang, P.S, Hsu, F.C, Huang, S.J, Mayo, S.L. 登録日 2013-10-26 公開日 2014-11-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Computational design and experimental verification of a symmetric protein homodimer. Proc.Natl.Acad.Sci.USA, 112, 2015

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