4OC2

X-ray structure of of human glutamate carboxypeptidase II (GCPII) in a complex with CEIBzL, a urea-based inhibitor N~2~-{[(1S)-1-carboxybut-3-yn-1-yl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine

Summary for 4OC2

Entry DOI	10.2210/pdb4oc2/pdb
Related	4OC0 4OC1 4OC3 4OC4 4OC5
Descriptor	Glutamate carboxypeptidase 2, CHLORIDE ION, N~2~-{[(1S)-1-carboxybut-3-yn-1-yl]carbamoyl}-N~6~-(4-iodobenzoyl)-L-lysine, ... (12 entities in total)
Functional Keywords	hydrolase, metallopeptidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
Total number of polymer chains	1
Total formula weight	83720.61
Authors	Pavlicek, J.,Ptacek, J.,Cerny, J.,Byun, Y.,Skultetyova, L.,Pomper, M.,Lubkowski, J.,Barinka, C. (deposition date: 2014-01-08, release date: 2014-05-21, Last modification date: 2020-07-29)
Primary citation	Pavlicek, J.,Ptacek, J.,Cerny, J.,Byun, Y.,Skultetyova, L.,Pomper, M.G.,Lubkowski, J.,Barinka, C. Structural characterization of P1'-diversified urea-based inhibitors of glutamate carboxypeptidase II. Bioorg.Med.Chem.Lett., 24:2340-2345, 2014 Cited by PubMed: 24731280 DOI: 10.1016/j.bmcl.2014.03.066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation