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PDB: 42 results
4WHY
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BU of 4why by Molmil
Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P21 crystal form
Descriptor: Heavy chain of Fab fragment derived from neutralizing antibody 3/11, Light chain of Fab fragment derived from neutralizing antibody 3/11, epitope peptide
Authors:Krey, T, Rey, F.A.
Deposit date:2014-09-24
Release date:2014-12-17
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein e2 recognized by broadly neutralizing antibodies.
J.Virol., 89, 2015
4WHT
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BU of 4wht by Molmil
Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form
Descriptor: Epitope peptide, Heavy chain of the Fab fragment derived from neutralizing antibody 3/11, Light chain of the Fab fragment derived from neutralizing antibody 3/11
Authors:Krey, T, Rey, F.A.
Deposit date:2014-09-23
Release date:2014-12-17
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein e2 recognized by broadly neutralizing antibodies.
J.Virol., 89, 2015
4OJC
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BU of 4ojc by Molmil
Crystal structure of the wild-type full-length trimeric ectodomain of the C. elegans fusion protein EFF-1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EFF-1A, ...
Authors:Krey, T, Rey, F.A.
Deposit date:2014-01-21
Release date:2014-05-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:Structural basis of eukaryotic cell-cell fusion
Cell(Cambridge,Mass.), 157, 2014
4OJE
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BU of 4oje by Molmil
Crystal structure of a C-terminally truncated trimeric ectodomain of the C. elegans fusion protein EFF-1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, EFF-1A, ...
Authors:Krey, T, Rey, F.A.
Deposit date:2014-01-21
Release date:2014-05-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structural basis of eukaryotic cell-cell fusion
Cell(Cambridge,Mass.), 157, 2014
4OJD
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BU of 4ojd by Molmil
Crystal structure of a C-terminally truncated trimeric ectodomain of the C. elegans fusion protein EFF-1 G260A/D321E/D322E mutant
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, EFF-1A, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Krey, T, Rey, F.A.
Deposit date:2014-01-21
Release date:2014-05-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural basis of eukaryotic cell-cell fusion
Cell(Cambridge,Mass.), 157, 2014
4JVP
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BU of 4jvp by Molmil
Three dimensional structure of broadly neutralizing anti - Hepatitis C virus (HCV) glycoprotein E2 alpaca nanobody D03
Descriptor: Anti-HCV E2 alpaca nanobody D03, SULFATE ION
Authors:Krey, T, Rey, F.A.
Deposit date:2013-03-26
Release date:2013-04-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission.
Hepatology, 58, 2013
4JZO
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BU of 4jzo by Molmil
Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-27
Descriptor: Anti-HCV E2 Fab HC84-27 heavy chain, Anti-HCV E2 Fab HC84-27 light chain, Envelope glycoprotein E2
Authors:Krey, T, Rey, F.A.
Deposit date:2013-04-03
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape.
Plos Pathog., 9, 2013
4JZN
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BU of 4jzn by Molmil
Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-1
Descriptor: Anti-HCV E2 Fab HC84-1 heavy chain, Anti-HCV E2 Fab HC84-1 light chain, Envelope glycoprotein E2, ...
Authors:Krey, T, Rey, F.A.
Deposit date:2013-04-03
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape.
Plos Pathog., 9, 2013
4DW7
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BU of 4dw7 by Molmil
Crystal structure of an active-site mutant of the glycoprotein Erns from the pestivirus BVDV-1 in complex with a CpU dinucleotide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYTIDINE-5'-MONOPHOSPHATE, ...
Authors:Krey, T, Bontems, F, Vonrhein, C, Vaney, M.-C, Bricogne, G, Ruemenapf, T, Rey, F.A.
Deposit date:2012-02-24
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.
Structure, 20, 2012
4DVN
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BU of 4dvn by Molmil
Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with 2'-UMP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E(rns) glycoprotein, ...
Authors:Krey, T, Bontems, F, Vonrhein, C, Vaney, M.-C, Bricogne, G, Ruemenapf, T, Rey, F.A.
Deposit date:2012-02-23
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.
Structure, 20, 2012
4DW5
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BU of 4dw5 by Molmil
Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with a non-cleavable CpU dinucleotide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E(rns) glycoprotein, ...
Authors:Krey, T, Bontems, F, Vonrhein, C, Vaney, M.-C, Bricogne, G, Ruemenapf, T, Rey, F.A.
Deposit date:2012-02-24
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.
Structure, 20, 2012
4DW4
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BU of 4dw4 by Molmil
Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with 5'-UMP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E(rns) glycoprotein, ...
Authors:Krey, T, Bontems, F, Vonrhein, C, Vaney, M.-C, Bricogne, G, Ruemenapf, T, Rey, F.A.
Deposit date:2012-02-24
Release date:2012-05-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.
Structure, 20, 2012
4DWC
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BU of 4dwc by Molmil
Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with Zn ions
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-D-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Krey, T, Bontems, F, Vonrhein, C, Vaney, M.-C, Bricogne, G, Ruemenapf, T, Rey, F.A.
Deposit date:2012-02-24
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.
Structure, 20, 2012
4DVK
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BU of 4dvk by Molmil
Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 strain NCP-7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E(rns) glycoprotein, ...
Authors:Krey, T, Bontems, F, Vonrhein, C, Vaney, M.-C, Bricogne, G, Ruemenapf, T, Rey, F.A.
Deposit date:2012-02-23
Release date:2012-05-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.
Structure, 20, 2012
4DW3
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BU of 4dw3 by Molmil
Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with 5'-CMP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYTIDINE-5'-MONOPHOSPHATE, ...
Authors:Krey, T, Bontems, F, Vonrhein, C, Vaney, M.-C, Bricogne, G, Ruemenapf, T, Rey, F.A.
Deposit date:2012-02-24
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.
Structure, 20, 2012
4DWA
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BU of 4dwa by Molmil
Crystal structure of an active-site mutant of the glycoprotein Erns from the pestivirus BVDV-1 in complex with a CpUpC trinucleotide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, E(rns) glycoprotein, ...
Authors:Krey, T, Bontems, F, Vonrhein, C, Vaney, M.-C, Bricogne, G, Ruemenapf, T, Rey, F.A.
Deposit date:2012-02-24
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.
Structure, 20, 2012
4DVL
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BU of 4dvl by Molmil
Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with 2'-3'-cyclo-UMP
Descriptor: 1-[(2S,3aS,4S,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4( 1H,3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Krey, T, Bontems, F, Vonrhein, C, Vaney, M.-C, Bricogne, G, Ruemenapf, T, Rey, F.A.
Deposit date:2012-02-23
Release date:2012-05-23
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.
Structure, 20, 2012
8PHI
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BU of 8phi by Molmil
Crystal structure of prefusion-stabilized RSV F Variant DS-Cav1 in complex with Lonafarnib
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, CALCIUM ION, ...
Authors:Rajak, M, Krey, T.
Deposit date:2023-06-19
Release date:2024-02-21
Method:X-RAY DIFFRACTION (2.289 Å)
Cite:Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor.
Nat Commun, 15, 2024
6S3D
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BU of 6s3d by Molmil
Structure of D25 Fab in complex with scaffold S0_2.126
Descriptor: Heavy Chain, Light Chain, S0_2.126
Authors:Cramer, J.T, Krey, T.
Deposit date:2019-06-25
Release date:2020-04-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:De novo protein design enables the precise induction of RSV-neutralizing antibodies.
Science, 368, 2020
3U6R
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BU of 3u6r by Molmil
Three dimensional structure of broadly neutralizing anti - Hepatitis C virus (HCV) glycoprotein E2 single chain FV fragment 1:7
Descriptor: Antibody 1:7 (Heavy chain), Antibody 1:7 (Light chain), SULFATE ION
Authors:Gilmartin, A.A, Lamp, B, Ruemenapf, T, Persson, A.A, Rey, F.A, Krey, T.
Deposit date:2011-10-12
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:High-level secretion of recombinant monomeric murine and human single-chain Fv antibodies from Drosophila S2 cells.
Protein Eng.Des.Sel., 25, 2012
5NPH
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BU of 5nph by Molmil
Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the Fab fragment of the non-neutralizing antibody DAO5
Descriptor: Genome polyprotein, Heavy chain of Fab fragment derived from non-neutralizing antibody DAO5, Light chain of Fab fragment derived from non-neutralizing antibody DAO5
Authors:Vasiliauskaite, I, Rey, F.A, Krey, T.
Deposit date:2017-04-16
Release date:2017-05-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2.
MBio, 8, 2017
5NPI
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BU of 5npi by Molmil
Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the single chain variable fragment of the non-neutralizing antibody DAO5
Descriptor: Epitope peptide, Single chain variable fragment of the non-neutralizing antibody DAO5
Authors:Vasiliauskaite, I, Rey, F.A, Krey, T.
Deposit date:2017-04-16
Release date:2017-05-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2.
MBio, 8, 2017
5MF1
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BU of 5mf1 by Molmil
Crystal structure of a C-terminally truncated trimeric ectodomain of the Chlamydomonas reinhardtii gamete fusion protein HAP2
Descriptor: 2-acetamido-2-deoxy-beta-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion protein HAP2/GCS1
Authors:Fedry, J, Rey, F.A, Krey, T.
Deposit date:2016-11-17
Release date:2017-03-08
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The Ancient Gamete Fusogen HAP2 Is a Eukaryotic Class II Fusion Protein.
Cell, 168, 2017
7NXE
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BU of 7nxe by Molmil
Structure of the Phospholipase C gamma 1 tSH2 domain in complex with a phosphorylated KSHV pK15 peptide
Descriptor: Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Protein K15
Authors:Ssebyatika, G, Krey, T.
Deposit date:2021-03-18
Release date:2021-06-09
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Recruitment of phospholipase C gamma 1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation.
Plos Pathog., 17, 2021
8BG8
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BU of 8bg8 by Molmil
SARS-CoV-2 S protein in complex with pT1696 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, pT1696 Fab heavy chain, ...
Authors:Hansen, G, Benecke, T, Vollmer, B, Gruenewald, K, Krey, T.
Deposit date:2022-10-27
Release date:2023-11-08
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Activity of broadly neutralizing antibodies against sarbecoviruses: a trade-off between SARS-CoV-2 variants and distant coronaviruses?
To be published

 

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