4JZN

Three dimensional structure of broadly neutralizing human anti - Hepatitis C virus (HCV) glycoprotein E2 Fab fragment HC84-1

Summary for 4JZN

• Entry DOI: 10.2210/pdb4jzn/pdb
• Related: 4JZO
• Descriptor: Anti-HCV E2 Fab HC84-1 heavy chain, Anti-HCV E2 Fab HC84-1 light chain, Envelope glycoprotein E2, ... (5 entities in total)
• Functional Keywords: fab fragment, immunglobulin fold, antibody, immune system, viral protein-immune system complex, immune system-viral protein complex, immune system/viral protein
• Biological source: Homo sapiens (human); More
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein. Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P27958
• Total number of polymer chains: 7
• Total formula weight: 153871.18

Authors

Krey, T.,Rey, F.A. (deposition date: 2013-04-03, release date: 2013-06-05, Last modification date: 2023-09-20)

• Primary citation: Krey, T.,Meola, A.,Keck, Z.Y.,Damier-Piolle, L.,Foung, S.K.,Rey, F.A.; Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape.; Plos Pathog., 9:e1003364-e1003364, 2013; PubMed: 23696737; DOI: 10.1371/journal.ppat.1003364

Experimental method

X-RAY DIFFRACTION (2.05 Å)