5NPH

Structure of the Hepatitis C virus strain J4 glycoprotein E2 antigenic region 532-540 bound to the Fab fragment of the non-neutralizing antibody DAO5

Summary for 5NPH

• Entry DOI: 10.2210/pdb5nph/pdb
• Descriptor: Genome polyprotein, Heavy chain of Fab fragment derived from non-neutralizing antibody DAO5, Light chain of Fab fragment derived from non-neutralizing antibody DAO5, ... (4 entities in total)
• Functional Keywords: envelope glycoprotein, hepatitis c virus, fab fragment, cd81 binding loop, immune system
• Biological source: Mus musculus (house mouse); More
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane ; Single-pass membrane protein . Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : O92972
• Total number of polymer chains: 3
• Total formula weight: 53026.65

Authors

Vasiliauskaite, I.,Rey, F.A.,Krey, T. (deposition date: 2017-04-16, release date: 2017-05-24, Last modification date: 2024-05-01)

• Primary citation: Vasiliauskaite, I.,Owsianka, A.,England, P.,Khan, A.G.,Cole, S.,Bankwitz, D.,Foung, S.K.H.,Pietschmann, T.,Marcotrigiano, J.,Rey, F.A.,Patel, A.H.,Krey, T.; Conformational Flexibility in the Immunoglobulin-Like Domain of the Hepatitis C Virus Glycoprotein E2.; MBio, 8:-, 2017; PubMed: 28512091; DOI: 10.1128/mBio.00382-17

Experimental method

X-RAY DIFFRACTION (1.7 Å)