7NXE

Structure of the Phospholipase C gamma 1 tSH2 domain in complex with a phosphorylated KSHV pK15 peptide

Summary for 7NXE

• Entry DOI: 10.2210/pdb7nxe/pdb
• Descriptor: Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, Protein K15 (3 entities in total)
• Functional Keywords: kshv, complex, phosphorylation, viral protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 29751.14

Authors

Ssebyatika, G.,Krey, T. (deposition date: 2021-03-18, release date: 2021-06-09, Last modification date: 2024-01-31)

• Primary citation: Samarina, N.,Ssebyatika, G.,Tikla, T.,Waldmann, J.Y.,Abere, B.,Nanna, V.,Marasco, M.,Carlomagno, T.,Krey, T.,Schulz, T.F.; Recruitment of phospholipase C gamma 1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation.; Plos Pathog., 17:e1009635-e1009635, 2021; PubMed: 34143834; DOI: 10.1371/journal.ppat.1009635

Experimental method

X-RAY DIFFRACTION (2.1 Å)