Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with 2'-3'-cyclo-UMP

Summary for 4DVL

Related4DVK 4DVN 4DW3
DescriptorE(rns) glycoprotein, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywordsvirus glycoprotein, t2 ribonuclease, viral protein
Biological sourceBovine viral diarrhea virus (BVDV)
Cellular locationE(rns) glycoprotein: Host membrane; Peripheral membrane protein. Envelope glycoprotein E2: Host cell surface (By similarity). Cysteine protease NS2: Host membrane; Multi- pass membrane protein (Potential) Q96662
Total number of polymer chains2
Total molecular weight43857.02
Krey, T.,Bontems, F.,Vonrhein, C.,Vaney, M.-C.,Bricogne, G.,Ruemenapf, T.,Rey, F.A. (deposition date: 2012-02-23, release date: 2012-05-23, Last modification date: 2020-07-29)
Primary citation
Krey, T.,Bontems, F.,Vonrhein, C.,Vaney, M.C.,Bricogne, G.,Rumenapf, T.,Rey, F.A.
Crystal Structure of the Pestivirus Envelope Glycoprotein E(rns) and Mechanistic Analysis of Its Ribonuclease Activity.
Structure, 20:862-873, 2012
PubMed: 22579253 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2012.03.018
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26160 4.6% 6.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-23