4DVL

Crystal structure of the glycoprotein Erns from the pestivirus BVDV-1 in complex with 2'-3'-cyclo-UMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0033897	molecular_function	ribonuclease T2 activity
B	0003723	molecular_function	RNA binding
B	0033897	molecular_function	ribonuclease T2 activity

Functional Information from PROSITE/UniProt

site_id	PS00531
Number of Residues	12
Details	RNASE_T2_2 Ribonuclease T2 family histidine active site 2. LqrHEWnKHGwC

Chain	Residue	Details
A	LEU73-CYS84

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: For E(rns) glycoprotein RNase activity => ECO:0000269|PubMed:22579253

Chain	Residue	Details
A	HIS76
A	GLU77
A	LYS80
A	HIS81
B	HIS76
B	GLU77
B	LYS80
B	HIS81

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Hydrogen donor to release the cleavage products of E(rns) glycoprotein RNase activity

Chain	Residue	Details
A	HIS32
B	HIS32

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site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000269|PubMed:22579253

Chain	Residue	Details
A	ASN4
B	ASN67
B	ASN97
B	ASN102
A	ASN13
A	ASN28
A	ASN67
A	ASN97
A	ASN102
B	ASN4
B	ASN13
B	ASN28

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; by host => ECO:0000255

Chain	Residue	Details
A	ASN145
B	ASN145

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