6RPC

GOLGI ALPHA-MANNOSIDASE II

Summary for 6RPC

Entry DOI	10.2210/pdb6rpc/pdb
Descriptor	Alpha-mannosidase 2, 1,2-ETHANEDIOL, SUCCINIC ACID, ... (5 entities in total)
Functional Keywords	mannosidase, glycoside hydrolase, hydrolase
Biological source	Drosophila melanogaster (Fruit fly)
Total number of polymer chains	1
Total formula weight	118825.97
Authors	Armstrong, Z.,Lahav, D.,Johnson, R.,Kuo, C.L.,Beenakker, T.J.M.,de Boer, C.,Wong, C.S.,Debets, M.,van der Stelt, M.,Codee, J.D.C.,Aerts, J.M.F.G.,Wu, L.,Overkleeft, H.S.,Davies, G.J. (deposition date: 2019-05-14, release date: 2020-07-08, Last modification date: 2024-01-24)
Primary citation	Armstrong, Z.,Kuo, C.L.,Lahav, D.,Liu, B.,Johnson, R.,Beenakker, T.J.M.,de Boer, C.,Wong, C.S.,van Rijssel, E.R.,Debets, M.F.,Florea, B.I.,Hissink, C.,Boot, R.G.,Geurink, P.P.,Ovaa, H.,van der Stelt, M.,van der Marel, G.M.,Codee, J.D.C.,Aerts, J.M.F.G.,Wu, L.,Overkleeft, H.S.,Davies, G.J. Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142:13021-13029, 2020 Cited by PubMed: 32605368 DOI: 10.1021/jacs.0c03880 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation