4MCQ
A high resolution structure of human glutamate carboxypeptidase II (GCPII) in complex with folyldi-gamma-L-glutamic acid (pteroyltri-gamma-L-glutamic acid)
Summary for 4MCQ
Entry DOI | 10.2210/pdb4mcq/pdb |
Related | 4MCP 4MCR 4MCS |
Related PRD ID | PRD_001164 |
Descriptor | Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | hydrolase, metallopeptidase, hydrolase-hydrolase inhibitor complex, prostate specific membrane antigen, folate hydrolase 1, folh1 |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609 |
Total number of polymer chains | 1 |
Total formula weight | 88564.40 |
Authors | Navratil, M.,Barinka, C. (deposition date: 2013-08-21, release date: 2014-06-18, Last modification date: 2020-07-29) |
Primary citation | Navratil, M.,Ptacek, J.,Sacha, P.,Starkova, J.,Lubkowski, J.,Barinka, C.,Konvalinka, J. Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II. Febs J., 281:3228-3242, 2014 Cited by PubMed: 24863754DOI: 10.1111/febs.12857 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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