4MCS

A high resolution structure of human glutamate carboxypeptidase II (GCPII) His475Tyr variant in complex with glutamic acid

Summary for 4MCS

Entry DOI	10.2210/pdb4mcs/pdb
Related	4MCP 4MCQ 4MCR
Descriptor	Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	zinc metallopeptidase, gcpii, prostate specific membrane antigen, folate hydrolase 1, folh1, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
Total number of polymer chains	1
Total formula weight	88228.07
Authors	Ptacek, J.,Barinka, C.,Sacha, P.,Navratil, M. (deposition date: 2013-08-21, release date: 2014-06-18, Last modification date: 2020-07-29)
Primary citation	Navratil, M.,Ptacek, J.,Sacha, P.,Starkova, J.,Lubkowski, J.,Barinka, C.,Konvalinka, J. Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II. Febs J., 281:3228-3242, 2014 Cited by PubMed: 24863754 DOI: 10.1111/febs.12857 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation