4MCQ

A high resolution structure of human glutamate carboxypeptidase II (GCPII) in complex with folyldi-gamma-L-glutamic acid (pteroyltri-gamma-L-glutamic acid)

Summary for 4MCQ

• Entry DOI: 10.2210/pdb4mcq/pdb
• Related: 4MCP 4MCR 4MCS
• Related PRD ID: PRD_001164
• Descriptor: Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: hydrolase, metallopeptidase, hydrolase-hydrolase inhibitor complex, prostate specific membrane antigen, folate hydrolase 1, folh1
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609
• Total number of polymer chains: 1
• Total formula weight: 88564.40

Authors

Navratil, M.,Barinka, C. (deposition date: 2013-08-21, release date: 2014-06-18, Last modification date: 2020-07-29)

• Primary citation: Navratil, M.,Ptacek, J.,Sacha, P.,Starkova, J.,Lubkowski, J.,Barinka, C.,Konvalinka, J.; Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II.; Febs J., 281:3228-3242, 2014; PubMed: 24863754; DOI: 10.1111/febs.12857

Experimental method

X-RAY DIFFRACTION (2 Å)