4MCS
A high resolution structure of human glutamate carboxypeptidase II (GCPII) His475Tyr variant in complex with glutamic acid
Summary for 4MCS
Entry DOI | 10.2210/pdb4mcs/pdb |
Related | 4MCP 4MCQ 4MCR |
Descriptor | Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total) |
Functional Keywords | zinc metallopeptidase, gcpii, prostate specific membrane antigen, folate hydrolase 1, folh1, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type II membrane protein. Isoform PSMA': Cytoplasm: Q04609 |
Total number of polymer chains | 1 |
Total formula weight | 88228.07 |
Authors | Ptacek, J.,Barinka, C.,Sacha, P.,Navratil, M. (deposition date: 2013-08-21, release date: 2014-06-18, Last modification date: 2020-07-29) |
Primary citation | Navratil, M.,Ptacek, J.,Sacha, P.,Starkova, J.,Lubkowski, J.,Barinka, C.,Konvalinka, J. Structural and biochemical characterization of the folyl-poly-gamma-l-glutamate hydrolyzing activity of human glutamate carboxypeptidase II. Febs J., 281:3228-3242, 2014 Cited by PubMed: 24863754DOI: 10.1111/febs.12857 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.83 Å) |
Structure validation
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