6S1X

X-ray structure of human glutamate carboxypeptidase II (GCPII)-E424M inactive mutant, in complex with a inhibitor KB1160

Summary for 6S1X

Entry DOI	10.2210/pdb6s1x/pdb
Descriptor	Glutamate carboxypeptidase 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	glutamate carboxypeptidase ii (gcpii); naaladase; prostate-specific membrane antigen; urea-based inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	83425.31
Authors	Barinka, C.,Kutil, Z. (deposition date: 2019-06-19, release date: 2020-05-13, Last modification date: 2020-07-29)
Primary citation	Kim, K.,Kwon, H.,Barinka, C.,Motlova, L.,Nam, S.,Choi, D.,Ha, H.,Nam, H.,Son, S.H.,Minn, I.,Pomper, M.G.,Yang, X.,Kutil, Z.,Byun, Y. Novel beta- and gamma-Amino Acid-Derived Inhibitors of Prostate-Specific Membrane Antigen. J.Med.Chem., 63:3261-3273, 2020 Cited by PubMed: 32097010 DOI: 10.1021/acs.jmedchem.9b02022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation