7WFC
 
 | | X-ray structure of HKU1-PLP2(Cys109Ser) catalytic mutant in complex with free ubiquitin | | 分子名称: | 1,2-ETHANEDIOL, 60S ribosomal protein L40, Papain-like protease, ... | | 著者 | Xiong, Y.X, Fu, Z.Y, Huang, H. | | 登録日 | 2021-12-26 | | 公開日 | 2022-12-28 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The substrate selectivity of papain-like proteases from human-infecting coronaviruses correlates with innate immune suppression.
Sci.Signal., 16, 2023
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6O4A
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6OAM
 | | Crystal Structure of ChlaDUB2 DUB domain | | 分子名称: | Deubiquitinase and deneddylase Dub2, Ubiquitin | | 著者 | Hausman, J.M, Das, C. | | 登録日 | 2019-03-17 | | 公開日 | 2020-04-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | | 主引用文献 | The Two Deubiquitinating Enzymes fromChlamydia trachomatisHave Distinct Ubiquitin Recognition Properties.
Biochemistry, 59, 2020
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7LTO
 | | Nse5-6 complex | | 分子名称: | Non-structural maintenance of chromosome element 5, Ubiquitin-like protein SMT3,DNA repair protein KRE29 chimera | | 著者 | Yu, Y, Li, S.B, Zheng, S, Tangy, S, Koyi, C, Wan, B.B, Kung, H.H, Andrej, S, Alex, K, Patel, D.J, Zhao, X.L. | | 登録日 | 2021-02-19 | | 公開日 | 2021-05-19 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6QML
 | | UCHL3 in complex with synthetic, K27-linked diubiquitin | | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ... | | 著者 | Murachelli, A.G, Sixma, T.K. | | 登録日 | 2019-02-07 | | 公開日 | 2020-02-26 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap.
Cell Chem Biol, 28, 2021
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3I3T
 | | Crystal structure of covalent ubiquitin-USP21 complex | | 分子名称: | ETHANAMINE, Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 21, ... | | 著者 | Neculai, D, Avvakumov, G.V, Walker, J.R, Xue, S, Butler-Cole, C, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2009-06-30 | | 公開日 | 2009-07-21 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | A strategy for modulation of enzymes in the ubiquitin system.
Science, 339, 2013
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7O2W
 | | Structure of the C9orf72-SMCR8 complex | | 分子名称: | Guanine nucleotide exchange protein SMCR8,Guanine nucleotide exchange protein SMCR8,Maltose/maltodextrin-binding periplasmic protein, Ubiquitin-like protein SMT3,Guanine nucleotide exchange C9orf72 | | 著者 | Noerpel, J, Cavadini, S, Schenk, A.D, Graff-Meyer, A, Chao, J, Bhaskar, V. | | 登録日 | 2021-03-31 | | 公開日 | 2021-07-21 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY | | 主引用文献 | Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture.
Plos Biol., 19, 2021
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7W3U
 | | USP34 catalytic domain in complex with UbPA | | 分子名称: | Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 34, ZINC ION, ... | | 著者 | Xu, G.L, Ming, Z.H. | | 登録日 | 2021-11-26 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | | 主引用文献 | Structural Insights into the Catalytic Mechanism and Ubiquitin Recognition of USP34.
J.Mol.Biol., 434, 2022
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3JSV
 | | Crystal structure of mouse NEMO CoZi in complex with Lys63-linked di-ubiquitin | | 分子名称: | NF-kappa-B essential modulator, Ubiquitin | | 著者 | Yoshikawa, A, Sato, Y, Mimura, H, Yamashita, M, Yamagata, A, Fukai, S. | | 登録日 | 2009-09-11 | | 公開日 | 2009-10-27 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin
Febs Lett., 583, 2009
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8CX9
 | | Structure of the SARS-COV2 PLpro (C111S) in complex with a dimeric Ubv that inhibits activity by an unusual allosteric mechanism | | 分子名称: | BROMIDE ION, CHLORIDE ION, Papain-like protease nsp3, ... | | 著者 | Singer, A.U, Slater, C.L, Patel, A, Russel, R, Mark, B.L, Sidhu, S.S. | | 登録日 | 2022-05-20 | | 公開日 | 2023-01-25 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site.
Plos Pathog., 18, 2022
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8CX2
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 2 | | 分子名称: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | 著者 | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | 登録日 | 2022-05-19 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
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8CX1
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC dimeric complex in State 1 | | 分子名称: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | 著者 | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | 登録日 | 2022-05-19 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
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8CX0
 | | Cryo-EM structure of human APOBEC3G/HIV-1 Vif/CBFbeta/ELOB/ELOC monomeric complex | | 分子名称: | Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, Elongin-B, ... | | 著者 | Li, Y, Langley, C, Azumaya, C.M, Echeverria, I, Chesarino, N.M, Emerman, M, Cheng, Y, Gross, J.D. | | 登録日 | 2022-05-19 | | 公開日 | 2023-02-15 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | The structural basis for HIV-1 Vif antagonism of human APOBEC3G.
Nature, 615, 2023
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8EBN
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8EBS
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8EBW
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8EBV
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8EFW
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8EFX
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8EWV
 | | DNA-encoded library (DEL)-enabled discovery of proximity inducing small molecules | | 分子名称: | Bromodomain-containing protein 4, Elongin-B, Elongin-C, ... | | 著者 | Schreiber, S.L, Shu, W, Ma, X, Michaud, G, Bonazzi, S, Berst, F. | | 登録日 | 2022-10-24 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | DNA-encoded library-enabled discovery of proximity-inducing small molecules.
Nat.Chem.Biol., 20, 2024
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8EI3
 | | Crystal structure of VHL in complex with H313, a Helicon Polypeptide | | 分子名称: | Elongin-B, Elongin-C, H313, ... | | 著者 | Li, K, Tokareva, O.S, Thomson, T.M, Verdine, G.L, McGee, J.H. | | 登録日 | 2022-09-14 | | 公開日 | 2023-10-25 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.49 Å) | | 主引用文献 | Recognition and reprogramming of E3 ubiquitin ligase surfaces by alpha-helical peptides.
Nat Commun, 14, 2023
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8EHO
 | | PRRSV-1 PLP2 domain bound to ubiquitin | | 分子名称: | 3-AMINOPROPANE, GLYCEROL, NITRATE ION, ... | | 著者 | Bailey-Elkin, B.A, Mark, B.L. | | 登録日 | 2022-09-14 | | 公開日 | 2023-12-06 | | 最終更新日 | 2024-01-03 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis.
Plos Pathog., 19, 2023
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8FVJ
 | | Dimeric form of HIV-1 Vif in complex with human CBF-beta, ELOB, ELOC, and CUL5 | | 分子名称: | Core-binding factor subunit beta, Cullin-5, Elongin-B, ... | | 著者 | Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. | | 登録日 | 2023-01-19 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H.
Nat Commun, 14, 2023
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8FVI
 | | Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5 | | 分子名称: | Core-binding factor subunit beta, Cullin 5, DNA dC->dU-editing enzyme APOBEC-3H, ... | | 著者 | Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S. | | 登録日 | 2023-01-19 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | | 主引用文献 | Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H.
Nat Commun, 14, 2023
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8FY0
 | | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) | | 分子名称: | Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... | | 著者 | Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. | | 登録日 | 2023-01-25 | | 公開日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | | 主引用文献 | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL.
Nat Commun, 15, 2024
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