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7PI4

FAK Protac GSK215 in complex with FAK and pVHL:ElonginC:ElonginB

This is a non-PDB format compatible entry.
Summary for 7PI4
Entry DOI10.2210/pdb7pi4/pdb
Descriptorvon Hippel-Lindau disease tumor suppressor, Elongin-B, Isoform 2 of Elongin-C, ... (9 entities in total)
Functional Keywordstransferase, protac
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight74404.45
Authors
Chung, C. (deposition date: 2021-08-19, release date: 2021-09-29, Last modification date: 2024-01-31)
Primary citationLaw, R.P.,Nunes, J.,Chung, C.W.,Bantscheff, M.,Buda, K.,Dai, H.,Evans, J.P.,Flinders, A.,Klimaszewska, D.,Lewis, A.J.,Muelbaier, M.,Scott-Stevens, P.,Stacey, P.,Tame, C.J.,Watt, G.F.,Zinn, N.,Queisser, M.A.,Harling, J.D.,Benowitz, A.B.
Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs.
Angew.Chem.Int.Ed.Engl., 60:23327-23334, 2021
Cited by
PubMed: 34416073
DOI: 10.1002/anie.202109237
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.24 Å)
Structure validation

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