7PI4

FAK Protac GSK215 in complex with FAK and pVHL:ElonginC:ElonginB

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	AAA	von Hippel-Lindau disease tumor suppressor	polymer	155	18012.5	1	UniProt (P40337) Pfam (PF01847) Pfam (PF17211) In PDB	Homo sapiens (Human)	Protein G7,pVHL
2	BBB	Elongin-B	polymer	105	11845.5	1	UniProt (Q15370) Pfam (PF00240) In PDB	Homo sapiens (Human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
3	CCC	Isoform 2 of Elongin-C	polymer	96	10843.4	1	UniProt (Q15369-2) In PDB	Homo sapiens (Human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
4	DDD	Focal adhesion kinase 1	polymer	273	31384.3	1	UniProt (Q05397) Pfam (PF07714) In PDB	Homo sapiens (Human)	FADK 1,Focal adhesion kinase-related nonkinase,FRNK,Protein phosphatase 1 regulatory subunit 71,PPP1R71,Protein-tyrosine kinase 2,p125FAK,pp125FAK
5	AAA	(2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)phenyl)piperazin-1-yl)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide	non-polymer		985.1	1	Chemie (7QB)
6	AAA, DDD	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	4	Chemie (PEG)
7	AAA, BBB, CCC, DDD	1,2-ETHANEDIOL	non-polymer		62.1	14	Chemie (EDO)
8	AAA	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
9		water	water		18.0	150	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	72085.8
Non-Polymers*	Number of molecules	20
	Total formula weight	2318.6
All*	Total formula weight	74404.5

*Water molecules are not included.