7PI4
FAK Protac GSK215 in complex with FAK and pVHL:ElonginC:ElonginB
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| BBB | 0006368 | biological_process | transcription elongation by RNA polymerase II |
| BBB | 0030891 | cellular_component | VCB complex |
| BBB | 0070449 | cellular_component | elongin complex |
| CCC | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| DDD | 0004672 | molecular_function | protein kinase activity |
| DDD | 0004713 | molecular_function | protein tyrosine kinase activity |
| DDD | 0005524 | molecular_function | ATP binding |
| DDD | 0006468 | biological_process | protein phosphorylation |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 27 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGQFGDVHqGiymspenpala.......VAIK |
| Chain | Residue | Details |
| DDD | ILE428-LYS454 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDIAARNVLV |
| Chain | Residue | Details |
| DDD | PHE542-VAL554 |
| site_id | PS00661 |
| Number of Residues | 31 |
| Details | FERM_2 FERM domain signature 2. HrdiaarnvlVSsndCVklgDfgLsrYMeDS |
| Chain | Residue | Details |
| DDD | HIS544-SER574 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 |
| Chain | Residue | Details |
| DDD | ASP546 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:12467573 |
| Chain | Residue | Details |
| DDD | ILE428 | |
| DDD | LYS454 | |
| DDD | GLU500 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| DDD | TYR570 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by RET and SRC => ECO:0000269|PubMed:15561106, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:21454698 |
| Chain | Residue | Details |
| DDD | TYR576 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by RET and SRC => ECO:0000269|PubMed:12387730, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:21454698 |
| Chain | Residue | Details |
| DDD | TYR577 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| DDD | SER580 |
