3KW5

Crystal structure of ubiquitin carboxy terminal hydrolase L1 bound to ubiquitin vinylmethylester

Summary for 3KW5

Related2ETL 3KVF
DescriptorUbiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin, METHYL 4-AMINOBUTANOATE (3 entities in total)
Functional Keywordsenzyme-suicide substrate complex, hydrolase, ligase, protease, thiol protease, ubl conjugation pathway, isopeptide bond, ubl conjugation, hydrolase-hydrolase inhibitor complex, acetylation, cytoplasm, disease mutation, glycoprotein, oxidation, polymorphism, nucleus, phosphoprotein, hydrolase-signaling protein complex, hydrolase/signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P09936
Total number of polymer chains2
Total molecular weight33903.72
Authors
Maiti, T.K.,Boudreaux, D.A.,Das, C. (deposition date: 2009-11-30, release date: 2010-06-16, Last modification date: 2011-07-13)
Primary citation
Boudreaux, D.A.,Maiti, T.K.,Davies, C.W.,Das, C.
Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation.
Proc.Natl.Acad.Sci.USA, 107:9117-9122, 2010
PubMed: 20439756 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0910870107
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.83 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.28250.7%3.9%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report