3I3T

Crystal structure of covalent ubiquitin-USP21 complex

Summary for 3I3T

• Entry DOI: 10.2210/pdb3i3t/pdb
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 21, Ubiquitin, ZINC ION, ... (5 entities in total)
• Functional Keywords: ubiquitin-specific protease activity, hydrolase, ubiquitin biology, structural genomics consortium, sgc, activator, chromatin regulator, nucleus, protease, thiol protease, transcription, transcription regulation, ubl conjugation pathway, isopeptide bond, phosphoprotein
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: Q9UK80
• Total number of polymer chains: 8
• Total formula weight: 194943.69

Authors

Neculai, D.,Avvakumov, G.V.,Walker, J.R.,Xue, S.,Butler-Cole, C.,Weigelt, J.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium (SGC) (deposition date: 2009-06-30, release date: 2009-07-21, Last modification date: 2023-09-06)

• Primary citation: Ernst, A.,Avvakumov, G.,Tong, J.,Fan, Y.,Zhao, Y.,Alberts, P.,Persaud, A.,Walker, J.R.,Neculai, A.M.,Neculai, D.,Vorobyov, A.,Garg, P.,Beatty, L.,Chan, P.K.,Juang, Y.C.,Landry, M.C.,Yeh, C.,Zeqiraj, E.,Karamboulas, K.,Allali-Hassani, A.,Vedadi, M.,Tyers, M.,Moffat, J.,Sicheri, F.,Pelletier, L.,Durocher, D.,Raught, B.,Rotin, D.,Yang, J.,Moran, M.F.,Dhe-Paganon, S.,Sidhu, S.S.; A strategy for modulation of enzymes in the ubiquitin system.; Science, 339:590-595, 2013; PubMed: 23287719; DOI: 10.1126/science.1230161

Experimental method

X-RAY DIFFRACTION (2.59 Å)