PDB: 9760 件ウェブページステータス検索Chemie searchBIRD

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1RHH	Crystal Structure of the Broadly HIV-1 Neutralizing Fab X5 at 1.90 Angstrom Resolution 分子名称: Fab X5, heavy chain, light chain 著者 Darbha, R, Phogat, S, Labrijn, A.F, Shu, Y, Gu, Y, Andrykovitch, M, Zhang, M.Y, Pantophlet, R, Martin, L, Vita, C, Burton, D.R, Dimitrov, D.S, Ji, X. 登録日 2003-11-14 公開日 2004-02-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal Structure of the Broadly Cross-Reactive HIV-1-Neutralizing Fab X5 and Fine Mapping of Its Epitope Biochemistry, 43, 2004
3JCX	Canine Parvovirus complexed with Fab E 分子名称: Capsid protein 2, Fab E heavy chain, Fab E light chain 著者 Organtini, L.J, Iketani, S, Huang, K, Ashley, R.E, Makhov, A.M, Conway, J.F, Parrish, C.R, Hafenstein, S. 登録日 2016-03-21 公開日 2016-07-20 最終更新日 2018-07-18 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Near-Atomic Resolution Structure of a Highly Neutralizing Fab Bound to Canine Parvovirus. J.Virol., 90, 2016
6PXH	Crystal Structure of MERS-CoV S1-NTD bound with G2 Fab 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DIHYDROFOLIC ACID, ... 著者 Wang, N, McLellan, J.S. 登録日 2019-07-26 公開日 2019-09-25 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD. Cell Rep, 28, 2019
3RZW	Crystal Structure of the Monobody ySMB-9 bound to human SUMO1 分子名称: GLYCEROL, Monobody ySMB-9, Small ubiquitin-related modifier 1 著者 Gilbreth, R.N, Koide, S. 登録日 2011-05-12 公開日 2011-12-28 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold. J.Mol.Biol., 415, 2012
6EQC	Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon 分子名称: Hexon protein, scFv of 9C12 antibody 著者 Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A. 登録日 2017-10-12 公開日 2018-02-07 最終更新日 2018-02-14 実験手法 ELECTRON MICROSCOPY (7.4 Å) 主引用文献 Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. Nat Commun, 9, 2018
3UYO	Crystal structure of monobody SH13/ABL1 SH2 domain complex 分子名称: Monobody SH13, SULFATE ION, Tyrosine-protein kinase ABL1 著者 Wojcik, J.B, Koide, A, Koide, S. 登録日 2011-12-06 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold. J.Mol.Biol., 415, 2012
3BN9	Crystal Structure of MT-SP1 in complex with Fab Inhibitor E2 分子名称: 1,2-ETHANEDIOL, E2 Fab Heavy Chain, E2 Fab Light Chain, ... 著者 Farady, C.J, Schneider, E.L, Egea, P.F, Goetz, D.H, Craik, C.S. 登録日 2007-12-13 公開日 2008-09-09 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.173 Å) 主引用文献 Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition J.Mol.Biol., 380, 2008
3MXV	Crystal structure of fab fragment of anti-Shh 5E1 chimera 分子名称: SULFATE ION, fab fragment of anti-Shh 5E1 mouse/human chimera, heavy chain, ... 著者 Hymowitz, S.G, Maun, H.R. 登録日 2010-05-07 公開日 2010-05-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site. J.Biol.Chem., 285, 2010
3MXW	Crystal structure Sonic hedgehog bound to the 5E1 fab fragment 分子名称: 5E1 heavy chain, 5E1 light chain, CALCIUM ION, ... 著者 Hymowitz, S.G, Maun, H.R. 登録日 2010-05-07 公開日 2010-05-26 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.83 Å) 主引用文献 Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site. J.Biol.Chem., 285, 2010
1ETZ	THE THREE-DIMENSIONAL STRUCTURE OF AN ANTI-SWEETENER FAB, NC10.14, SHOWS THE EXTENT OF STRUCTURAL DIVERSITY IN ANTIGEN RECOGNITION BY IMMUNOGLOBULINS 分子名称: FAB NC10.14 - HEAVY CHAIN, FAB NC10.14 - LIGHT CHAIN, N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID 著者 Guddat, L.W, Shan, L, Broomell, C, Ramsland, P.A, Fan, Z, Anchin, J.M, Linthicum, D.S, Edmundson, A.B. 登録日 2000-04-13 公開日 2000-10-18 最終更新日 2017-10-04 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The three-dimensional structure of a complex of a murine Fab (NC10. 14) with a potent sweetener (NC174): an illustration of structural diversity in antigen recognition by immunoglobulins. J.Mol.Biol., 302, 2000
8V7O	Fab fragment of human mAb #58 in complex with computationally optimized broadly reactive H1 influenza hemagglutinin X6 分子名称: #58 heavy chain, #58 light chain, Hemagglutinin 著者 Nagashima, K.A, Mousa, J.J. 登録日 2023-12-04 公開日 2024-04-10 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.57 Å) 主引用文献 Structural basis for the broad antigenicity of the computationally optimized influenza hemagglutinin X6. Structure, 2024
1HZH	CRYSTAL STRUCTURE OF THE INTACT HUMAN IGG B12 WITH BROAD AND POTENT ACTIVITY AGAINST PRIMARY HIV-1 ISOLATES: A TEMPLATE FOR HIV VACCINE DESIGN 分子名称: IMMUNOGLOBULIN HEAVY CHAIN, IMMUNOGLOBULIN LIGHT CHAIN,Uncharacterized protein, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Saphire, E.O, Burton, D.R, Wilson, I.A. 登録日 2001-01-24 公開日 2001-08-15 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. Science, 293, 2001
8DT8	LM18/Nb136 bispecific tetra-nanobody immunoglobulin in complex with SARS-CoV-2-6P-Mut7 S protein (focused refinement) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, LM18 nanobody, Nb136 nanobody, ... 著者 Ozorowski, G, Turner, H.L, Ward, A.B. 登録日 2022-07-25 公開日 2023-06-14 実験手法 ELECTRON MICROSCOPY (3.34 Å) 主引用文献 Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins. Proc.Natl.Acad.Sci.USA, 120, 2023
1MHH	Structure of P. magnus protein L mutant bound to a mouse Fab 分子名称: 1,2-ETHANEDIOL, Fab, heavy chain, ... 著者 Graille, M, Stura, E.A. 登録日 2002-08-20 公開日 2003-01-14 最終更新日 2018-01-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Evidence for plasticity and structural mimicry at the immunoglobulin light chain-protein L interface J.Biol.Chem., 277, 2002
6VKN	BG505 SOSIP.v5.2.N241.N289 in complex with rhesus macaque Fab RM19R 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Cottrell, C.A, Ward, A.B. 登録日 2020-01-21 公開日 2020-08-12 最終更新日 2020-09-02 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. NPJ Vaccines, 5, 2020
2D03	Crystal structure of the G91S mutant of the NNA7 Fab 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Xie, K, Song, S.C, Spitalnik, S.L, Wedekind, J.E. 登録日 2005-07-23 公開日 2006-01-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Crystallographic analysis of the NNA7 Fab and proposal for the mode of human blood-group recognition. Acta Crystallogr.,Sect.D, 61, 2005
6QU9	Fab fragment of an antibody that inhibits polymerisation of alpha-1-antitrypsin 分子名称: FAB 4B12 heavy chain, FAB 4B12 light chain, GLYCEROL, ... 著者 Jagger, A.M, Heyer-Chauhan, N, Lomas, D.A, Irving, J.A. 登録日 2019-02-26 公開日 2020-03-18 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The structural basis for Z alpha 1 -antitrypsin polymerization in the liver. Sci Adv, 6, 2020
5TRU	Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4 分子名称: Cytotoxic T-lymphocyte protein 4, Ipilimumab Fab heavy chain, Ipilimumab Fab light chain 著者 Ramagopal, U.A, Liu, W, Garrett-Thomson, S.C, Yan, Q, Srinivasan, M, Wong, S.C, Bell, A, Mankikar, S, Rangan, V.S, Deshpande, S, Bonanno, J.B, Korman, A.J, Almo, S.C. 登録日 2016-10-27 公開日 2017-05-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
1PKQ	Myelin Oligodendrocyte Glycoprotein-(8-18C5) Fab-complex 分子名称: (8-18C5) chimeric Fab, heavy chain, light chain, ... 著者 Breithaupt, C, Schubart, A, Zander, H, Skerra, A, Huber, R, Linington, C, Jacob, U. 登録日 2003-06-06 公開日 2003-07-15 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein Proc.Natl.Acad.Sci.USA, 100, 2003
6Y54	Crystal structure of a Neisseria meningitidis serogroup A capsular oligosaccharide bound to a functional Fab 分子名称: 1,2-ETHANEDIOL, Fab A1.1 H chain, Fab A1.1 L chain, ... 著者 Dello Iacono, L, Henriques, P, Adamo, R. 登録日 2020-02-24 公開日 2020-10-07 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide. Proc.Natl.Acad.Sci.USA, 117, 2020
8EKF	X-ray crystal structure of 311R Fab in complex with the PfCSP peptide NPNA-3 分子名称: 311R Heavy Chain, 311R Light Chain, PfCSP peptide NPNA-3 著者 Moskovitz, R, Wilson, I.A. 登録日 2022-09-20 公開日 2022-10-19 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Affinity-matured homotypic interactions induce spectrum of PfCSP structures that influence protection from malaria infection. Nat Commun, 14, 2023
8VUC	Structure of FabS1CE2-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, S1CE2 VARIANT OF FAB-EPR-1 heavy chain, ... 著者 Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S. 登録日 2024-01-29 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024
8VUA	Structure of FabS1CE1-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor 分子名称: S1CE1 VARIANT OF FAB-EPR-1 heavy chain, S1CE1 VARIANT OF FAB-EPR-1 light chain 著者 Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S. 登録日 2024-01-29 公開日 2024-07-10 実験手法 X-RAY DIFFRACTION (3.27 Å) 主引用文献 Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024
9ERX	Structural basis of D9-THC analog activity at the Cannabinoid 1 receptor 分子名称: (6aR,10aR)-9-(hydroxymethyl)-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, Antibody ScFv16 Fab fragment, Cannabinoid receptor 1, ... 著者 Thorsen, T.S, Kulkarni, Y, Boggild, A, Drace, T, Nissen, P, Gajhede, M, Boesen, T, Kastrup, J.S, Gloriam, D. 登録日 2024-03-25 公開日 2024-06-26 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis of Delta 9 -THC analog activity at the Cannabinoid 1 receptor. Res Sq, 2024
8VTR	Structure of FabS1CE3-EPR-1, an elbow-locked high affinity antibody for the erythropoeitin receptor (orthorhombic form) 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, CITRIC ACID, ... 著者 Singer, A.U, Bruce, H.A, Pavlenco, A, Ploder, L, Luu, G, Blazer, L, Adams, J.J, Sidhu, S.S. 登録日 2024-01-26 公開日 2024-07-10 最終更新日 2024-07-24 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Antigen-binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones. Protein Sci., 33, 2024

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