5TRU

Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4

Summary for 5TRU

• Entry DOI: 10.2210/pdb5tru/pdb
• Descriptor: Ipilimumab Fab light chain, Ipilimumab Fab heavy chain, Cytotoxic T-lymphocyte protein 4 (3 entities in total)
• Functional Keywords: antibody, complex, fab, immune system
• Biological source: Homo sapiens; More
• Cellular location: Cell membrane ; Single-pass type I membrane protein : P16410
• Total number of polymer chains: 6
• Total formula weight: 120693.16

Authors

Ramagopal, U.A.,Liu, W.,Garrett-Thomson, S.C.,Yan, Q.,Srinivasan, M.,Wong, S.C.,Bell, A.,Mankikar, S.,Rangan, V.S.,Deshpande, S.,Bonanno, J.B.,Korman, A.J.,Almo, S.C. (deposition date: 2016-10-27, release date: 2017-05-10, Last modification date: 2023-10-04)

• Primary citation: Ramagopal, U.A.,Liu, W.,Garrett-Thomson, S.C.,Bonanno, J.B.,Yan, Q.,Srinivasan, M.,Wong, S.C.,Bell, A.,Mankikar, S.,Rangan, V.S.,Deshpande, S.,Korman, A.J.,Almo, S.C.; Structural basis for cancer immunotherapy by the first-in-class checkpoint inhibitor ipilimumab.; Proc. Natl. Acad. Sci. U.S.A., 114:E4223-E4232, 2017; PubMed: 28484017; DOI: 10.1073/pnas.1617941114

Experimental method

X-RAY DIFFRACTION (3 Å)