5TRU

Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0006955	biological_process	immune response
C	0016020	cellular_component	membrane
C	0042129	biological_process	regulation of T cell proliferation
c	0006955	biological_process	immune response
c	0016020	cellular_component	membrane
c	0042129	biological_process	regulation of T cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR199-HIS205
L	TYR193-HIS199

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11279502, ECO:0000269|PubMed:16002699, ECO:0000269|PubMed:21156796

Chain	Residue	Details
c	ASN78
C	ASN78

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11279502, ECO:0000269|PubMed:16002699

Chain	Residue	Details
c	ASN110
C	ASN110

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