5TRU

Structure of the first-in-class checkpoint inhibitor Ipilimumab bound to human CTLA-4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (L, l)	Ipilimumab Fab light chain	polymer	215	23477.0	2		Homo sapiens
2	B, D (H, h)	Ipilimumab Fab heavy chain	polymer	225	24232.1	2		Homo sapiens
3	E, F (c, C)	Cytotoxic T-lymphocyte protein 4	polymer	118	12637.4	2	UniProt (P16410) Pfam (PF07686)	Homo sapiens (Human)	Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	120693.2
All*	Total formula weight	120693.2

*Water molecules are not included.