3MXV

Crystal structure of fab fragment of anti-Shh 5E1 chimera

Summary for 3MXV

• Entry DOI: 10.2210/pdb3mxv/pdb
• Related: 3MXW
• Descriptor: fab fragment of anti-Shh 5E1 mouse/human chimera, light chain, fab fragment of anti-Shh 5E1 mouse/human chimera, heavy chain, SULFATE ION, ... (4 entities in total)
• Functional Keywords: chimera, fab fragment, antibody, sonic hedgehog, immune system
• Biological source: Mus musculus, Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 48013.31

Authors

Hymowitz, S.G.,Maun, H.R. (deposition date: 2010-05-07, release date: 2010-05-26, Last modification date: 2023-09-06)

• Primary citation: Maun, H.R.,Wen, X.,Lingel, A.,de Sauvage, F.J.,Lazarus, R.A.,Scales, S.J.,Hymowitz, S.G.; Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.; J.Biol.Chem., 285:26570-26580, 2010; PubMed: 20504762; DOI: 10.1074/jbc.M110.112284

Experimental method

X-RAY DIFFRACTION (1.9 Å)