Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3MXW

Crystal structure Sonic hedgehog bound to the 5E1 fab fragment

Summary for 3MXW
Entry DOI10.2210/pdb3mxw/pdb
Related1VHH 3M1N 3MXV
DescriptorSonic hedgehog protein, 5E1 light chain, 5E1 heavy chain, ... (7 entities in total)
Functional Keywordsantibody complex, fab fragment, metalloprotease, calcium binding, zinc hydrolase, development, morphogen, signaling protein
Biological sourceHomo sapiens (human)
More
Cellular locationSonic hedgehog protein C-product: Secreted, extracellular space (By similarity). Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor (By similarity): Q15465
Total number of polymer chains3
Total formula weight66879.98
Authors
Hymowitz, S.G.,Maun, H.R. (deposition date: 2010-05-07, release date: 2010-05-26, Last modification date: 2023-09-06)
Primary citationMaun, H.R.,Wen, X.,Lingel, A.,de Sauvage, F.J.,Lazarus, R.A.,Scales, S.J.,Hymowitz, S.G.
Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.
J.Biol.Chem., 285:26570-26580, 2010
Cited by
PubMed: 20504762
DOI: 10.1074/jbc.M110.112284
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.83 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon