3M1N

Crystal structure of Human Sonic Hedgehog N-terminal domain

Summary for 3M1N

Entry DOI	10.2210/pdb3m1n/pdb
Descriptor	Sonic hedgehog protein, ZINC ION, SULFATE ION, ... (4 entities in total)
Functional Keywords	hedgehog proteins, signaling, zinc ions, sulfate ions, autocatalytic cleavage, cell membrane, developmental protein, glycoprotein, holoprosencephaly, hydrolase, lipoprotein, membrane, microphthalmia, palmitate, protease, secreted, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Sonic hedgehog protein C-product: Secreted, extracellular space (By similarity). Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor (By similarity): Q15465
Total number of polymer chains	2
Total formula weight	40429.81
Authors	Boriack-Sjodin, P.A.,Pepinsky, R.B.,Garber, E.A.,Silvian, L.F. (deposition date: 2010-03-05, release date: 2010-03-16, Last modification date: 2023-09-06)
Primary citation	Pepinsky, R.B.,Rayhorn, P.,Day, E.S.,Dergay, A.,Williams, K.P.,Galdes, A.,Taylor, F.R.,Boriack-Sjodin, P.A.,Garber, E.A. Mapping sonic hedgehog-receptor interactions by steric interference. J.Biol.Chem., 275:10995-11001, 2000 Cited by PubMed: 10753901 DOI: 10.1074/jbc.275.15.10995 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation